Quantitative Assessment of the Intracranial Vasculature of Infants and Adults Using iCafe (Intracranial Artery Feature Extraction).
Quantitative Assessment of the Intracranial Vasculature of Infants and Adults Using iCafe (Intracranial Artery Feature Extraction).
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DOI：
10.3389/fneur.2021.668298
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发表时间：
2021
影响因子：
3.4
通讯作者：
Yuan C
中科院分区：
文献类型：
--
作者：
Chen L;Shaw DWW;Dager SR;Corrigan NM;Chu B;Kleinhans NM;Kuhl PK;Hwang JN;Yuan C
颅内动脉特征的全面量化有助于评估和了解早期脑发育和衰老过程中血液供应的区域变化。我们分析了27名自然睡眠时的健康婴儿、13名7个月（7.3 ± 1.0个月）、14名12个月（11.7 ± 0.4个月）的婴儿以及13名年龄较大的健康清醒成人（62.8 ± 8.7岁）的血管特征，以研究年龄相关的血管差异，作为与大脑发育相关的血管变化的初步研究。在iCafe中处理3D飞行时间（TOF）磁共振血管造影（MRA）采集，这是一种量化动脉特征的技术（http：//www.example.com），以表征颅内血管系统。总体而言，与7个月和12个月婴儿相比，成人受试者的ACA长度、迂曲度和血管密度增加，与7个月婴儿相比，MCA长度增加。在婴儿或成人年龄组中，没有观察到任何血管测量的大脑偏侧差异。在婴儿中观察到颅骨和大脑清晰度降低，分别表明头部运动和大脑/血管脉动增加，但与长度、迂曲度或血管密度测量无关。应用iCafe对TOF MRA进行定量分析，可为系统研究婴儿脑血管发育及成人和小儿脑血管疾病的临床评估提供客观方法。
Comprehensive quantification of intracranial artery features may help to assess and understand regional variations of blood supply during early brain development and aging. We analyzed vasculature features of 27 healthy infants during natural sleep, 13 infants at 7-months (7.3 ± 1.0 month), and 14 infants at 12-months (11.7 ± 0.4 month), and 13 older healthy, awake adults (62.8 ± 8.7 years) to investigate age-related vascular differences as a preliminary study of vascular changes associated with brain development. 3D time-of-flight (TOF) magnetic resonance angiography (MRA) acquisitions were processed in iCafe, a technique to quantify arterial features (http://icafe.clatfd.cn), to characterize intracranial vasculature. Overall, adult subjects were found to have increased ACA length, tortuosity, and vasculature density compared to both 7-month-old and 12-month-old infants, as well as MCA length compared to 7-month-old infants. No brain laterality differences were observed for any vascular measures in either infant or adult age groups. Reduced skull and brain sharpness, indicative of increased head motion and brain/vascular pulsation, respectively, were observed in infants but not correlated with length, tortuosity, or vasculature density measures. Quantitative analysis of TOF MRA using iCafe may provide an objective approach for systematic study of infant brain vascular development and for clinical assessment of adult and pediatric brain vascular diseases.
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影响因子：
2.5
作者：
Schindelin J;Rueden CT;Hiner MC;Eliceiri KW
通讯作者：
Eliceiri KW
影响因子：
4.2
作者：
Bullitt, Elizabeth;Zeng, Donglin;Mortamet, Benedicte;Ghosh, Arpita;Aylward, Stephen R.;Lin, Weili;Marks, Bonita L.;Smith, Keith
通讯作者：
Smith, Keith
使用 iCafe 对老年人群的颅内脉管系统进行定量评估
影响因子：
4.2
作者：
Chen, Li;Sun, Jie;Yuan, Chun
通讯作者：
Yuan, Chun
影响因子：
5.9
作者：
Liu, Wenjin;Huang, Xiaoqin;Yang, Junwei
通讯作者：
Yang, Junwei
影响因子：
1.9
作者：
Nakagawara, J;Takeda, R;Nakamura, J
通讯作者：
Nakamura, J