Systems-Level Research in Microbial Pathogenesis

项目总结 《微生物致病机理的系统级研究》培训计划将正规化并加强 微生物发病机制的跨学科研究和询问寄生虫的高通量科学， 真菌、细菌和病毒在系统层面上更加完整。马里兰大学巴尔的摩分校 在微生物学、传染病、疫苗学、基因组学和生物信息学方面具有非凡的实力和深度 拥有100名在这些领域从事研究的教职员工。19名高级培训人员和7名初级培训人员 教员来自医学院的世界级微生物发病机制研究项目， 牙科和药学；包括来自该大学两个国际知名研究项目的科学家 研究所-疫苗开发中心和基因组科学研究所。这些教职员工有 在过去十年中出版了1000种出版物和93笔赠款，平均每年直接费用为1,707,495美元。他们会 开发和参与一门新的研究生课程，目标是这些受训者，目标是跨学科 微生物发病机制研究和系统水平研究的交叉点。博士前实习生将被 选自两个跨系博士项目，包括共同的核心课程，选修课 课程、期刊俱乐部、研讨会、年度研讨会和研究生研究报告。选定的 博士前学生还将包括医学院医学/博士项目和麻省理工学院 牙科DDS/PHD项目。学术工作将与严格的有指导的研究培训相结合 培训学院的研究小组，目前和过去的培训资助符合条件的博士前学员 平均每名学员发表论文4.0篇。博士后实习生将通过招聘新的 马里兰大学巴尔的摩分校研究员。我们的培训资助符合条件的博士后学员一直是 同样富有成效，每名受训人员有4.5份出版物。该项目由一个由三名合作伙伴组成的高素质团队指导。 董事(MPI)，其中两人担任轨道领导者，以及内部执行委员会。一个外部的 咨询委员会也已经成立，将对该计划进行评估。我们的学员将走得更远 通过课程的改变，侧重于微生物发病机制的系统水平研究，以及 独特的机会，将有助于招收和发展更多的学生在这一领域。那些计划 从较大的研究生群体中区分受训人员，以促进和加强他们的培训，包括(I) 在每年一度的马里兰大学校际相声研讨会上作口头报告，(Ii)定期培训 方案研究会议，(3)研究生和医学课程的教学机会，(4) 出席国家或国际会议，(5)出席内部研讨会系列会议的机会，(6) 正式的职业指导和以职业为重点的网络，以及(7)正式的指导和培训 从科学界代表性较低的群体中辅导本科生或高中生，帮助 建立我们强大的渠道，培养多样化的科学家。

PROJECT SUMMARY This training program in “Systems-Level Research in Microbial Pathogenesis” will formalize and strengthen interdisciplinary research in microbial pathogenesis and high-throughput science that interrogates parasites, fungi, bacteria, and viruses more completely at the systems-level. The University of Maryland Baltimore has exceptional strength and depth in microbiology, infectious disease, vaccinology, genomics, and bioinformatics with >100 faculty with research in these areas. The nineteen senior training faculty and seven junior training faculty are drawn from the world class microbial pathogenesis research programs in the Schools of Medicine, Dentistry, and Pharmacy; including scientists from two of the university's internationally renowned research institutes—the Center for Vaccine Development and the Institute for Genome Sciences. These faculty have >1000 publications in the past ten years and 93 grants with average direct costs of $1,707,495/year. They will develop and participate in a new graduate course targeting these trainees that is aimed at interdisciplinary research at the intersection of microbial pathogenesis and systems-level research. Predoctoral trainees will be selected from two interdepartmental doctoral programs that include a common core curriculum, elective courses, journal clubs, seminars, annual symposia, and graduate research presentations. The selected predoctoral students will also include trainees from the School of Medicine MD/PhD program and the School of Dentistry DDS/PhD program. Academic work will be combined with rigorous mentored research training in the research groups of the training faculty, who have current and past training grant eligible predoctoral trainees with an average of 4.0 publications/trainee. Postdoctoral trainees will be selected through recruitment of new fellows to the University of Maryland Baltimore. Our training grant eligible postdoctoral trainees have been equally productive with 4.5 publications/trainee. The program is guided by a highly qualified team of three Co- Directors (MPIs) with two serving as track leaders, as well as an internal Executive Committee. An External Advisory Committee has also been established that will evaluate the program. Our trainees will be further focused on systems-level research in microbial pathogenesis through a change in our curriculum, as well as unique opportunities that will aid in recruitment and development of more students in this area. Programs that distinguish trainees from the larger pool of graduate students, to promote and enhance their training, include (i) oral presentations at the annual University of Maryland intercampus Crosstalk symposium, (ii) regular training program research meetings, (iii) teaching opportunities in graduate and medical courses, (iv) opportunities to present at national or international conferences, (v) opportunities to present in internal seminar series, (vi) formalized career mentoring and career-focused networking, and (vii) formal training in mentorship and mentoring an undergraduate or high school student from groups typically underrepresented in science, helping to build our robust pipeline for developing diverse scientists.