Core M: Implementation Science

摘要 艾滋病毒预防和治疗干预措施的进展，以及前所未有的投资， 这些干预措施的规模，提供了一个机会，以防止新的感染，避免艾滋病毒相关的发病率， 死亡率，并极大地改变了艾滋病毒/艾滋病的流行。然而，艾滋病毒科学进步的全部潜力 治疗和预防尚未实现，有效的干预措施尚未充分扩大规模 有效的方案。实施科学可以提高这些计划的吸收和有效性， 并在人口水平上影响健康。鉴于必须将循证干预措施转化为 广泛实施的计划，实施科学是国家卫生研究院，国内和全球的科学优先事项 公共卫生机构和UW/Fred Hutch CFAR成员。 华盛顿大学/弗雷德哈奇CFAR是理想的位置，继续连接实施科学研究与公众 美国的健康项目，和全球范围内。我们的CFAR教师是在定义前沿 多学科的，实施科学研究方法，并已制定了新的培训课程，在公共 健康和实施科学。此外，CFAR附属调查人员领导各种项目， 实施和扩大艾滋病毒预防和治疗干预措施， 与整个美国和国际卫生部门的关系。 在上一次竞争性更新中，我们将实施科学科学工作组转变为 在CFAR社区内发展实施科学专业知识的核心， 跨学科实施科学研究，并将研究与公共卫生活动联系起来，以促进 在现实世界的公共卫生环境中实施科学。在下一个续约期，我们建议继续 为初级研究人员提供高价值的培训机会，导致新的和创新的研究， 提高艾滋病毒预防和护理科学证据转化工作的速度、效率和质量 转化为有效的大规模健康项目信息系统核心的具体目标是：1）建设艾滋病毒方面的能力， 通过短期课程和研讨会进行重点实施科学研究; 2）增加外部 资助国内和国际以艾滋病毒为重点的实施科学研究;和3）制定一个 通过初级教育，培养艾滋病毒/艾滋病实施科学研究的早期研究人员骨干 调查员指导小组。为了推进这些目标，信息系统核心将支持培训和研讨会， 培养研究人员与实施科学相关的技能并吸引新的研究人员进入该领域;提供 为CFAR附属研究人员提供有关赠款申请的咨询和分析专业知识，并支持正在进行的 在与执行科学有关的领域开展项目; 国际和国内卫生部门确定和培养合作研究;并支持三个 青年教师的18个月的指导经验，以促进竞争力的研究提案的队列。

Abstract Advances in HIV prevention and treatment interventions, together with unprecedented investments to bring these interventions to scale, presents an opportunity to prevent new infections, avert HIV-related morbidity and mortality, and dramatically alter the HIV/AIDS epidemic. However, the full potential of scientific advances in HIV treatment and prevention has yet to be realized, and efficacious interventions have not been adequately scaled into effective programs. Implementation science can improve the uptake and effectiveness of these programs, and impact health at the population level. Given the imperative to translate evidence-based interventions into widely implemented programs, implementation science is a scientific priority for the NIH, domestic and global public health agencies, and UW/Fred Hutch CFAR members. The UW/Fred Hutch CFAR is ideally situated to continue to link implementation science research with public health programs both within the U.S., and globally. Our CFAR faculty is at the forefront in defining multidisciplinary, implementation science research methods, and has developed novel training curricula in public health and implementation science. Furthermore, CFAR-affiliated investigators lead diverse programs to implement and scale-up HIV prevention and treatment interventions that have developed strong, collaborative relationships with health departments throughout the U.S. and internationally. In the last competitive renewal, we transitioned the Implementation Science Scientific Working Group into a Core that developed implementation science expertise within the CFAR community, fostered new interdisciplinary implementation science research, and linked research and public health activities to promote implementation science in real-world public health settings. For the next renewal period we propose to continue high value training opportunities for junior researchers, lead to new and innovative research, and ultimately improve the speed, efficiency, and quality of efforts to translate scientific evidence on HIV prevention and care into effective, large scale health programs. The IS Core’s specific aims are to: 1) Build capacity in HIV- focused implementation science research through short courses and seminars; 2) Increase externally funded domestic and international HIV-focused implementation science research; and 3) Develop a cadre of early-stage investigators in implementation science HIV/AIDS research through a Junior Investigator Mentorship Group. To advance these aims the IS Core will support trainings and seminars to build investigators’ skills related to implementation science and draw new researchers into the field; provide consulting and analytic expertise to CFAR-affiliated researchers on grant applications and in support of ongoing projects in areas related to implementation science; create linkages between CFAR investigators and international and domestic health departments to identify and cultivate collaborative research; and support three cohorts of junior faculty for an 18-month mentorship experience to foster competitive research proposals.