A Multicomponent Intervention to Increase HIV Risk Perceptions and PrEPInitiation among Black Men Who Have Sex With Men

项目摘要/摘要 可悲的是，美国男男性接触者(BMSM)中的艾滋病毒感染仍在继续。 尽管暴露前预防(PrEP)的有效性和兴趣，但BMSM中的有效感染 仍然很低。当务之急是减少这一群体启动PrEP的障碍，这可能需要艾滋病毒 结合行为、生物医学和结构策略的干预措施。提出的理论指导下， 多成分干预旨在增强人们对艾滋病毒风险的认知，并增加预防接种计划的启动 巴尔的摩市的BMSM，使用现有的移动智能手机应用程序和同行变更代理 记录和审查性危险行为，并鼓励开展PrEP。拟议的研究和培训 计划将在此指导研究科学家发展奖(K01)提案中提供主要 调查员Derek T.Dangerfield II，博士，拥有干预设计所需的技能，以发展成为 富有成效的独立调查员。提出的研究和培训目标解决了艾滋病毒方面的一个关键差距 预防；众所周知，现有的工作未能显著降低BMSM的感染 在全美范围内，为了从战略上推进这些培训目标，K01提案旨在促进 作为一名正在崛起的独立调查员的专业发展和研究能力。有针对性的课程作业， 授课工作坊，以及临床干预设计、LIFE领域专家的深入指导 课程中结合了健康理论方法和统计分析，以便于动手操作 应用新开发的技能的机会。技术、同行和PrEP的组合使用可充分利用 现有的多成分干预的相关预防策略。本研究具有创新性和创新性。 它及时响应了联邦和学术界的呼吁，要求仔细考虑，跨学科干预，以 减少重点人群中的艾滋病毒发病率。这项建议的目的是将定性和定量相结合 运用定量研究方法探讨干预因素对偏好度的影响 在人群中进行准备入门。这项研究对于理解这些方法是否 此干预中使用的可应用于临床设置或可应用于基于同伴的设置 绕过传统医疗服务的障碍。丹格菲尔德博士的主要导师是 高级研究员Jason Farley，博士，公共卫生硕士，ANP-BC，约翰霍普金斯大学护理学院FAAN， 约翰·霍普金斯大学彭博公共卫生学院克里斯·拜勒博士的补充指导 Bluthenthal(南加州大学凯克医学院)和Renata Arrington-Sanders(Johns 霍普金斯大学医学院)。通过研究、教学指导和培训，丹格菲尔德博士将建立 凭借他在行为社会科学方面的专业知识，他在设计高影响力产品方面取得了成功， 采取多种临床干预措施，减少健康差距。

PROJECT SUMMARY/ABSTRACT Tragically, HIV infections among Black men who have sex with men (BMSM) in the U.S. persist. Despite the availability and interest in pre-exposure prophylaxis (PrEP), effective uptake among BMSM remains low. It is imperative to mitigate barriers to PrEP initiation among this group, which could require HIV interventions that incorporate behavioral, biomedical, and structural strategies. The proposed theory-guided, multi-component intervention is designed to enhance HIV risk perceptions and increase PrEP initiation among BMSM in Baltimore City, using an existing mobile smartphone application along with peer change agents to record and review sexual risk behaviors and encourage PrEP initiation. The proposed research and training plan in this Mentored Research Scientist Developmental Award (K01) proposal will provide the principal investigator, Derek T. Dangerfield II, PhD, with the skills needed in intervention design to develop into a productive, independent investigator. The research and training aims proposed address a critical gap in HIV prevention; it is well established that extant work has failed to substantially lower infections among BMSM throughout the U.S. To strategically advance these training aims, this K01 proposal is crafted to facilitate professional development and research capacities as a rising independent investigator. Targeted course work, didactic workshops, and in-depth mentorship from experts in the domains of clinical intervention design, life course theoretical approaches to health, and statistical analysis are incorporated to facilitate hands-on opportunities to apply newly developed skills. The combined use of technology, peers, and PrEP leverages existing relevant prevention strategies for a multi-component intervention. This research is innovative and timely as it responds to federal and academic calls for carefully considerate, interdisciplinary interventions to reduce HIV incidence among priority populations. The aims of this proposal incorporate qualitative and quantitative research methods to explore the preferences of the components of an intervention to increase PrEP initiation among the population. This research has implications for understanding whether the methods used in this intervention can be applied in clinical settings or can be applied in peer-based settings to circumvent the barriers of traditional healthcare engagement. Dr. Dangerfield will be primarily mentored by senior investigator Jason Farley, PhD, MPH, ANP-BC, FAAN at the Johns Hopkins School of Nursing, with additional mentoring from Drs. Chris Beyrer (Johns Hopkins Bloomberg School of Public Health), Ricky Bluthenthal (University of Southern California Keck School of Medicine), and Renata Arrington-Sanders (Johns Hopkins School of Medicine). Through research and didactic mentoring and training, Dr. Dangerfield will build upon his expertise in behavioral social science to develop a successful career in designing high-impact, multicomponent clinical interventions and reduce health disparities.