New Cures from Old Medicines - Targeting abnormal metabolism in Alzheimer's Disease

DREAM研究于2019年9月16日开始。已经测试了10种药物降低阿尔茨海默病和相关痴呆（ADRD）风险的能力。这些药物通常用于治疗类风湿性关节炎。其中一种药物测试的令人鼓舞的结果正在通过基于细胞培养分析的平行验证实验得到证实。下一组分析将测试常用的抗哮喘药物。由于COVID-19大流行造成的延误，已批准免费延长9个月，以便完成对20种候选药物的拟议分析。

The DREAM study began on 9/16/2019. 10 drugs have been tested for their ability to lower the risk of Alzheimer's disease and related dementias (ADRD). These drugs are commonly used to treat rheumatoid arthritis. Encouraging results from one of the drugs tested are being confirmed through parallel validation experiments in cell culture based assays. The next set of analyses will test commonly used anti-asthma drugs. Due to delays arising from the COVID-19 pandemic, a no-cost extension of 9-months has been granted to allow for the completion of proposed analyses of 20 candidate drugs.