Population Science and Cancer Control Program

人口科学和癌症控制(PS)计划寻求产生研究发现，解决 西蒙斯综合癌症中心(SCCC)德克萨斯州北部集水区的癌症负担和差异 区域和更远的地方。PS计划的具体目标是：(1)识别和评估生物标记物以评估癌症 风险，及早发现，并预测进展，(2)在多个层面上确定与癌症相关的因素 预防和早期发现、诊断、治疗和生存护理的提供、过程和结果， 以及(3)开发和测试干预措施，以改善循证癌症预防和 控制服务，重点是服务不足的人群和安全网医疗系统。PS计划 强调从预防和早期发现到治疗和治疗的整个癌症连续体的研究 生存，致力于将发现转化为跨疾病地点和三个目标的研究。 PS计划由Simon Craddock Lee博士、公共卫生硕士和Amit Singal医学博士共同领导 有27名成员，分布在德克萨斯大学西南医学中心(UTSW)的七个部门和两个部门 德克萨斯大学公共卫生学院达拉斯地区校区的各系。调查人员招募并 自2014年以来，该学院的成员包括生物统计学、数据科学、流行病学、地理空间等领域的专家 科学、卫生服务研究、社会心理学和烟草控制。PS计划的资金基础是 呈上升趋势，目前总筹资基数为590万美元，预计由于关键的新项目，这一数字将加快 在项目中进行招聘。在总金额中，98%(580万美元)是经过同行审查的，其中310万美元来自NCI。这个 与2014年的数据相比，PS计划的总研究资金基数增加了9%， 已进行调整，以符合修订后的癌症中心支持补助金指南。不包括在2019年 研究基础是为支持该计划的两个项目的基础设施和核心提供的大量资金 基于人口的研究，以优化筛查过程(PROSPR)合作协议。这个 复杂的数据收集基础设施对于支持与PROSPR和 其合作努力的主旨是增加我们对医疗保健系统、提供者和个人的了解- 影响癌症筛查质量的水平因素和SCCC对未得到充分服务的人群的关注。The PS 项目已经擅长于进行假设驱动的研究，通常是通过大规模的实用主义试验 设计，以促进癌症预防和控制中的护理提供。自2014年以来，PS计划成员 撰写了498份同行评议的出版物：31%代表方案内工作，34%代表方案间工作 合作，49%是跨机构的。

The Population Science and Cancer Control (PS) Program seeks to generate research discoveries addressing cancer burden and disparities in the Simmons Comprehensive Cancer Center’s (SCCC) North Texas catchment area and beyond. The PS Program specific aims are to: (1) identify and evaluate biomarkers to assess cancer risk, detect it early, and predict progression, (2) identify factors, at multiple levels, that are associated with cancer prevention and early detection, diagnosis, treatment, and survivorship care delivery, processes, and outcomes, and (3) develop and test interventions to improve implementation of evidence-based cancer prevention and control services, with a focus on underserved populations and safety-net healthcare systems. The PS Program emphasizes research across the cancer continuum from prevention and early detection, through treatment and survivorship, working to translate discoveries to inform research across disease sites and across the three aims. The PS Program is co-led by Simon Craddock Lee, PhD, MPH, and Amit Singal, MD, MS. The PS Program has 27 members, across seven departments in the UT Southwestern Medical Center (UTSW) and two departments in the Dallas Regional Campus of the UT School of Public Health. Investigators recruited and appointed to the faculty since 2014 include experts in biostatistics, data science, epidemiology, geospatial science, health services research, social psychology, and tobacco control. The PS Program’s funding base is on an upward trend, with a current total funding base of $5.9M, which is predicted to accelerate due to key new recruitments into the program. Of the total amount, 98% ($5.8M) is peer-reviewed, with $3.1M from the NCI. The PS Program’s total research funding base represents an increase of 9% compared with 2014 data, which have been adjusted to conform with the revised Cancer Center Support Grant guidelines. Not included in the 2019 research base is the significant amount of funding for the infrastructure and cores that support the program’s two Population-based Research to Optimize the Screening Process (PROSPR) cooperative agreements. The sophisticated data collection infrastructure is essential in supporting the projects associated with PROSPR and the thrust of its cooperative effort to increase our understanding of healthcare system, provider, and individual- level factors that affect the quality of cancer screening and SCCC’s focus on underserved populations. The PS Program has become adept at conducting hypothesis-driven research, often through large pragmatic trial designs, to advance care delivery in cancer prevention and control. Since 2014, PS Program members have authored 498 peer-reviewed publications: 31% represent intraprogrammatic work, 34% are interprogrammatic collaborations, and 49% are interinstitutional.