Core--Scientific

描述(由申请人提供)： 康涅狄格州大学ARC的行政和科学核心旨在确保中心内所有拟议和正在进行的研究活动以协调、高效和富有成效的方式运作(行政核心)，并确保相关项目(科学核心)有效地共享多项研究支持设施和公共资源。中心续签申请的第一部分(核心部分)描述了中心的组织框架、中心首席调查员/科学主任的权力和作用、质量控制机制、两个核心设施(生物统计学、临床评估单位)提供的服务以及行政核心/科学核心的各种职能。主要职能包括：预算编制、财政规划、资源配置、科学致富。专业发展、设施改进、新技术的获取、信息管理、为临床研究、数据管理和分析提供与临床人群的联系，以及接触由不同项目共享的生物统计支助小组和临床研究评价股。 康涅狄格州大学ARC使命的一个重要部分是作为地方、地区和国家资源，为信息传播、科学咨询、继续教育和促进学术交流提供服务。在拟议的资助期内，这些活动将采取赞助持续教育工作坊(例如，筛查和简短干预、酒精依赖的药物治疗、临床评估等)、分发专业教育培训材料、提供有关酒精政策的咨询、期刊编辑责任、支持来访的外国科学家和博士后培训等形式。 本部分还介绍了康涅狄格州大学ARC的科学核心资源以及与医学院内其他几个相关资源(GCRC、功能磁共振成像、衰老中心、转基因设施)的联系。该中心的设施包括生物统计学支持小组和临床研究和评估股(CREU)。这些核心设施通过提供不同项目共享的专业知识、人员、实验室设施和专门设备，以及作为博士后研究员、访问科学家和精神病学住院医师的培训场所，为中心的总体目标做出贡献。

DESCRIPTION (provided by applicant): The Administrative and Scientific Cores of the UConn ARC are designed to assure that all proposed and ongoing research activities within the Center function in a co-ordinated, efficient and productive fashion (Administrative Core) and that multi-study support facilities and common resources are shared effectively by related projects (Scientific Cores). Component I (Core Component) of the Center's renewal application describes the Center's organizational framework, the authority and roles of the Center's Principal Investigator / Scientific Director, quality control mechanisms, services provided by the two Core facilities (biostatistics, clinical evaluation unit), and the various functions of the Administrative Core / Scientific Core. The major functions include: budgeting, fiscal planning, resource allocation, scientific enrichment. Professional development, facilities improvement, acquisition of new technologies, information management, providing linkages to clinical populations for clinical research, data management and analysis, and access to a biostatistical support group and a clinical research evaluation unit shared by various projects. An important part of the UConn ARC's mission is to serve as a local, regional, and national resource for information dissemination, scientific consultation, continuing education, and the facilitation of scholarly exchanges. In the proposed grant period, these activities will take the form of sponsorship of continuing education workshops (e.g., screening and brief intervention, pharmacotherapy of alcohol dependence, clinical assessment, etc.), dissemination of professional education training materials, providing consultation regarding alcohol policy, journal editorial responsibilities, support for visiting foreign scientists, and post-doctoral training. This component also describes the scientific core resources of the UConn ARC and linkages to several other relevant resources (GCRC, fMRI, Center on Aging, transgenic facility) within the School of Medicine. The Core's facilities include the Biostatistics Support Group and the Clinical Research and Evaluation Unit (CREU). These core facilities contribute to the overall goals of the Center by providing expertise, personnel, laboratory facilities and specialized equipment that are shared by different projects and by serving as training sites for post-doctoral fellows, visiting scientists, and psychiatry residents.