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中文摘要
翻译
项目总结 行政核心旨在为所有缔约国提供行政监督和行政支持。 胰腺癌项目和核心。管理核心将监控所有计划的活动 组件,确保遵守地方和联邦拨款管理准则,并促进 计划成员之间的沟通和协作。行政核心的具体目标是: 目标1:促进孢子内和孢子间的交流、合作和会议。这个核心将是 负责分发与孢子有关的材料、议程、监管信息、进度报告和 面向全体教职员工的出版物。我们将协调每两个月一次的工作组会议,每月一次的孢子 指导委员会会议,以及年度务虚会,以促进思想交流和共享资源的使用。 我们将协调外部咨询委员会和内部咨询委员会。我们将保持一支敬业的 提供进度更新和联系信息的网站,向调查人员分发季度更新 重点介绍通过生物统计和生物信息学(核心B)和生物统计和生物信息学(核心C)提供的资源 并促进生物样品和信息的双向流动。这一核心还将提供 多机构孢子临床试验的行政监督。 目标2:为所有孢子组成部分提供行政和财政监督和支助。我们将互动 与华盛顿大学拨款和合同办公室和国家癌症研究所的工作人员一起准备和 提交年度进度报告,并根据需要完成其他项目。 目标3:协调孢子发展研究计划和职业发展计划 行政活动。该核心将征集申请并协调对职业提升的审查 计划(CEP)和发展研究计划(DRP)。该核心将监测获奖者的进展情况, 协调获奖者到同行孢子机构的旅行,并促进获奖者使用核心资源。 目标4:加强代表人数不足的少数群体参与所有孢子活动。核心将监督 促进少数人参与孢子临床试验和胰腺癌的DRP和CEP倡议 研究。我们将通过领导力、社区推广和教育、临床服务、 临床试验应计审计,支持差异研究,保留和招募少数族裔,以及 与制度差异资源进行沟通。 目标5:确保在与患者参与者的研究的所有方面都解决了倡导问题。这个 CORE将确保所有孢子组成部分适当地纳入宣传问题或关切。我们会 通过两种方式实现这一点,包括患者倡导和患者反馈。 目标6:协助调查人员准备学术报告、出版物、规章文件、 以及所有其他与孢子有关的产品。该核心将负责完成所需的文件 调查人员在地方和国家会议上发言并向机构监管机构提交文件 支持机构(例如,人类和动物研究方案)、出版物和最后经同行评审的手稿 在被接受后,立即由孢子资金转移到PubMed Central。
英文摘要
PROJECT SUMMARY The Administrative Core aims to provide executive oversight and administrative support for all SPORE in Pancreatic Cancer projects and cores. The Administrative Core will monitor the activities of all program components, ensure compliance with local and federal grant administration guidelines, and facilitate communication and collaboration among program members. The specific aims of the Administrative Core are: Aim 1: Facilitate intra- and inter-SPORE communication, collaboration, and meetings. This core will be responsible for distributing SPORE-related materials, agendas, regulatory information, progress reports, and publications to SPORE faculty and staff. We will coordinate bi-monthly working group meetings, monthly SPORE Steering Committee meetings, and an annual retreat to facilitate exchange of ideas and use of shared resources. We will coordinate the External Advisory Board and Internal Advisory Board. We will maintain a dedicated website to provide progress updates and contact information, distribute quarterly updates to investigators highlighting resources available through the Biospecimen (Core B) and Biostatistics & Bioinformatics (Core C) Cores, and facilitate bidirectional flow of biospecimen samples and information. This core will also provide administrative oversight of multi-institution SPORE clinical trials. Aim 2: Provide administrative and fiscal oversight and support for all SPORE components. We will interact with Washington University's Grants and Contracts Office and National Cancer Institute staff to prepare and submit annual progress reports and complete other projects as needed. Aim 3: Coordinate the SPORE Developmental Research Program and Career Enhancement Program administrative activities. This core will solicit applications and coordinate review for the Career Enhancement Program (CEP) and Developmental Research Program (DRP). This core will monitor awardee progress, coordinate awardees’ travel to peer SPORE institutions, and facilitate use of core resources by awardees. Aim 4: Enhance participation of underrepresented minorities in all SPORE activities. The Core will oversee DRP and CEP initiatives to promote minority participation in SPORE clinical trials and pancreatic cancer research. We will accomplish this through leadership, community outreach and education, clinical services, clinical trial accrual auditing, support of disparities research, retention and recruitment of minorities, and communication with institutional disparities resources. Aim 5: Ensure advocacy issues are addressed in all aspects of research with patient participants. The Core will ensure that all SPORE components properly incorporate advocacy issues or concerns. We will accomplish this in two ways including patient advocacy and patient feedback. Aim 6: Assist investigators in preparing scholarly presentations, publications, regulatory documents, and all other SPORE-related products. This core will be responsible for completing documentation required for investigators presenting at local and national meetings and submitting of documents to institutional regulatory bodies (e.g., human and animal studies protocols), publications, and final peer-reviewed manuscripts supported by SPORE funds to PubMed Central immediately upon acceptance.
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Project 2: Mechanisms of Resistance to Neoantigen Vaccines in PDAC
  • 批准号:
    10708575
  • 项目类别:
  • 资助金额:
    $33.69万
  • 财政年份:
    2023
  • 负责人:
    WILLIAM G HAWKINS
  • 依托单位:
Preclinical development of the novel inhibitor of apoptosis proteins S2/IAPinh for cancer therapy
  • 批准号:
    10568409
  • 项目类别:
  • 资助金额:
    $34.67万
  • 财政年份:
    2022
  • 负责人:
    WILLIAM G HAWKINS
  • 依托单位:
Preclinical Development of ACXT-3102 for the Treatment of Pancreatic Adenocarcinoma (PDAC)
  • 批准号:
    10435565
  • 项目类别:
  • 资助金额:
    $101.92万
  • 财政年份:
    2019
  • 负责人:
    WILLIAM G HAWKINS
  • 依托单位:
Preclinical Development of ACXT-3102 for the Treatment of Pancreatic Adenocarcinoma (PDAC)
  • 批准号:
    10251498
  • 项目类别:
  • 资助金额:
    $101.47万
  • 财政年份:
    2019
  • 负责人:
    WILLIAM G HAWKINS
  • 依托单位:
海外基金