INIA-STRESS: Informatics and Analysis Core

描述(由申请人提供)：信息和分析核心(BINFO)将提供几个不同的功能，以服务于INIA压力调查和项目。由于INIA-Stress研究项目的范围和多样性，BINFO的一般作用将是在研究项目之间提供标准化的研究支持和关键的综合职能。BINFO将为实验设计、高级统计分析、数据仓库或数据库存储以及高级生物信息学分析提供支持，包括开发或调整用于分析基因网络的新算法。BINFO包括四个不同机构(弗吉尼亚联邦大学、橡树岭国家实验室、田纳西大学诺克斯维尔分校和范德比尔特大学)的调查人员，并将根据不同的学科分为分核心，并涉及来自多个地点的专业知识。BINFOC的分核心和相关目标是：1)提供一个网络信息系统(www.iniastress.org)，它将具有公共和INIA-Stress限制功能；2)为所有INIA-Stress项目提供先进的实验设计和统计支持；3)为INIA-Stress数据集的基因网络注释(INIAGestalt)分析和基因网络整合提供算法和协助；以及4)为INIA-Stress微阵列实验的实验设计、分析和数据库管理提供专门知识和工具。总之，联布综合办将为本提案所有主要项目的数据整合和高级数据分析提供一个论坛。此外，BINFO提供的工具和资源将为酒精研究社区和其他生物医学研究人员提供服务。

DESCRIPTION (provided by applicant): he Informatics and Analysis Core (BINFO) will provide several distinct functions to serve INIA-Stress investigators and projects. Because of the scope and diversity of INIA-Stress research projects, the general role of the BINFO will be to provide standardized research support and key integrative functions among the research projects. The BINFO will provide support for experimental design, advanced statistical analysis, data warehousing or database storage, and advanced bioinformatics analysis, including development or adaptation of novel algorithms for analysis of gene networks. The BINFO encompasses investigators at four different institutions (Virginia Commonwealth University, Oak Ridge National Laboratory, University of Tennessee at Knoxville and Vanderbilt University) and will be divided into subcores based upon different disciplines and involve expertise from multiple sites. The subcores and related aims of the BINFOC are: 1) Provide a web-based information system (www.iniastress.org) that will have both public and INIA-Stress restricted functions; 2) Provide advanced experimental design and statistical support for all INIA-Stress projects; 3) Provide algorithms and assistance for gene-network annotation (INIAGestalt) analysis and gene network integration across INIA-Stress datasets; and 4) Provide expertise and tools for experimental design, analysis and database management of microarray experiments for INIA-Stress. Altogether the BINFO will provide a forum for both data integration and advanced data analysis across all the primary projects of this proposal. In addition, the tools and resources provided by the BINFO will provide service to the alcohol research community and other biomedical researchers.