WIHS Data Management and Analysis Center (WDMAC)

描述（改编自申请书，第328页）：本提案的目的是证明，在强有力的治疗时代，与感染艾滋病毒的妇女的自然史有关的关键假设，可以通过对参加妇女机构间艾滋病毒研究（WIHS）的个人进行持续随访来最好地解决。WIHS成立于1993年，目的是研究美国妇女的艾滋病毒疾病，它汇集了一个经验丰富的研究网络和广泛的基础设施，作为尖端实验室和临床科学的平台。参与者包括传统上未被充分研究的人群，但WIHS已经制定了有效的策略来成功地保持保留和随访，从而确保他们的长期特征和结果的确定。为了充分利用在定期访问中收集的综合数据，已经实施了最先进的分析方法，以评估治疗开始前后收集的因素与广泛的有益和不良结果之间的关系。除了作为核心WIHS研究的一部分检验重要假设外，我们还创建了一个数据和标本的研究平台，这是当前和未来研究的重要工具。该平台允许WIHS社区内外的调查人员使用纵向收集的数据和标本来检验新的假设，从而避免了重新编译所需资源的成本。这项研究是高度协作的，通过研究者发起的研究（r01和其他机制）与众多研究者共享数据和标本，并通过与WIHS相关的早期职业发展奖励支持新的临床科学家。这些要素中的每一项都对持续的生产力作出了贡献，截至本报告提交时已出版了大约320份出版物。WIHS的科学和操作部分是复杂和动态的。本申请的A部分将描述自2002年3月提交以来发生的队列和主要科学成就；介绍我们的科学和组织结构；我们提出的科学假设和2007-2012年的研究议程被组织成四个相互关联的研究项目和六个核心。

DESCRIPTION (adapted from application, page 328): The purpose of this proposal is to demonstrate that key hypotheses related to the natural history of HIV-infected women in the era of potent therapy can be best addressed through continued follow up of individuals enrolled in the Women's Interagency HIV Study (WIHS). Established in 1993 to study HIV disease among women in the U.S., the WIHS has assembled an experienced research network and an extensive infrastructure that serves as a platform for cutting-edge laboratory and clinical science. Participants encompass a traditionally understudied population, yet WIHS has developed effective strategies to successfully maintain retention and follow up, thus ensuring their long-term characterization and the ascertainment of outcomes. To capitalize upon the comprehensive data collected at regularly scheduled visits, state-of-the art analytical approaches have been implemented to assess the association of factors collected prior to and after therapy initiation with a broad spectrum of beneficial and adverse outcomes. In addition to testing important hypotheses as part of the core WIHS study, we have created a research platform of data and specimens that constitutes an important tool for current and future studies. This platform permits investigators inside and outside the WIHS community to use longitudinally collected data and specimens to test new hypotheses, and thus avoid the costs of compiling needed resource de novo. The study has been highly collaborative, sharing data and specimens with a multitude of investigators funded through investigator-initiated studies (R01s and other mechanisms) and in supporting new clinical scientists via WIHS linked early career development awards. Each of these elements has contributed to continued productivity, with some 320 publications as of this submission. The scientific and operational components of the WIHS are complex and dynamic. Part A of this application will describe the cohort and key scientific achievements that have occurred since our previous submission in March 2002; a presentation of our scientific and organizational structure; and our proposed scientific hypotheses and a research agenda for 2007-2012 that has been organized into four interrelated research projects and six cores.