Training in HIV Replication and Pathogenesis

描述(由申请人提供)：拟议的博士前培训计划的总体目标是为满足国家健康和研究重点的需要，贡献具有高度创造性、生产力和训练有素的艾滋病毒/艾滋病研究人员。这一目标将通过在罗切斯特大学医学和牙科学院(URMSD)成熟的跨部门研究生培训环境中培训一批博士前学生来实现，并在经验丰富和关心他人的导师的监督下进行。这一高度互动的核心环境将通过以下方式促进：致力于卓越的教学和研究并致力于艾滋病毒/艾滋病研究培训的教员；该计划教员杰出的艾滋病毒/艾滋病研究计划；艾滋病毒/艾滋病研究各个方面的讲座和有组织的研讨会；期刊俱乐部；精心设计的充实活动和研讨会；以及促进学员的数量。在艾滋病毒/艾滋病研究的范围内，有经验的导师将向学员提供各种相关问题的研究机会，这些导师拥有雄厚的外部资金和既定的合作历史。该计划的具体目标如下：1.建立一个互动的、富有成效的和令人兴奋的跨学科环境，使博士前学员在艾滋病毒/艾滋病研究领域获得卓越的教育。这将通过整合几个不同系和学科的教员来实现。2.为学生提供丰富的培训和学习环境，包括技能讲习班、有组织的研讨会方案和期刊俱乐部、杰出的校外演讲者、职业发展活动、加强负责任的研究工作培训以及辅导培训机会。学生还将接受评估和撰写手稿以及拨款申请的培训。3.通过上述计划促进学员和教职员工之间的沟通。这将利用市建局提供的亲密环境，所有参与的教职员和受训人员在同一物理空间、同一屋檐下共同工作。4.支持三个主要重点领域的培训工作：(1)病毒复制和逆转录，(2)病毒免疫学和疫苗生物学，(3)病毒发病机制，特别强调神经艾滋病和控制病毒复制的宿主因素。

DESCRIPTION (provided by applicant): The overall goal of the proposed predoctoral training program is to contribute highly creative, productive and well trained HIV/AIDS researchers to meet national health and research priorities. This goal will be achieved by having a cadre of predoctoral students train in the well-established interdepartmental graduate training milieu of the University of Rochester School of Medicine and Dentistry (URMSD), under the supervision of experienced and caring mentors. This highly interactive core environment will be fostered by: a faculty dedicated to excellence in teaching and research and committed to training in HIV/AIDS research; outstanding HIV/AIDS research programs of the program faculty; lecture courses and structured seminars in various aspects of HIV/AIDS research; journal clubs; well-designed enrichment activities and workshops; and a catalytic number of trainees. Research opportunities in a wide variety of relevant problems within the purview of HIV/AIDS research will be offered to trainees by experienced mentors with strong extramural funding and an established history of collaboration. Specific objectives of the program are as follows: 1. To develop an interactive, productive and exciting interdisciplinary environment in which predoctoral trainees obtain an outstanding education in the area of HIV/AIDS research. This will be achieved by integrating faculty from several different departments and disciplines. 2. To provide an enriched training and learning environment for students, with skills workshops, structured seminar programs and journal clubs, distinguished extramural speakers, career development activities, enhanced training in the responsible conduct of research, and opportunities for training in mentoring. Students will also be trained to evaluate and write both manuscripts and grant applications. 3. To foster communication among trainees and faculty through the programs outlined above. This will exploit the intimate environment provided at the URSMD, where all the participating faculty and trainees work together in the same physical space, under a single roof. 4. To support training efforts in three major emphasis areas: (i) viral replication and reverse transcription, (ii) viral immunology and vaccine biology, and (iii) viral pathogenesis, with special emphasis on neuroAIDS and host factors that control virus replication.