Integrative Systems Biology Core

项目摘要/摘要 综合系统生物学核心将与所有研究人员互动，以开发和应用适当的分析 最有效地实现项目目标的方法和设计。我们将确保实验数据是 进行适当的分析，以检验与每个项目相关的假设。此外，综合系统 BioCore将为所有研究数据的安全管理提供基础设施和监督，并密切合作 使用生物试剂和资源核心，以促进所有项目和 调查人员。我们的具体目标是：(1)将尖端分析方法整合到设计、分析、 和解释我们计划中的项目的实验研究；以及(2)提供安全和 可访问的数据库系统和计算基础设施，以促进可靠和可重复的分析 由所有项目调查人员进行。综合系统生物学核心利用教师和资源 在凯斯综合癌症中心、凯斯西储大学医学院和 杜克分子生理学研究所。Thomas LaFramboise博士将与Simon Gregory博士共同领导核心 作为联席导演。综合系统生物学核心将作为所有人员的集中资源， 包括三个研究项目的负责人和生物制剂与资源核心。核心将协助 调查人员具有全方位的设计、计算分析和解释能力。既是既定的，也是新颖的 可使用量身定制的分析方法来促进核心内部研究人员的科学发现。堆芯 工作人员将在研究的所有阶段与调查人员互动，从数据管理、数据分析、 口译、撰写科学手稿和补助金、传播成果。核心还将 促进对安全且可访问的数据库系统的访问，促进分析、发现和 协作。核心将协助所有调查人员进行项目的开发、管理和可靠性 数据，还将整合跨数据库的信息，例如整合临床和实验数据 使用由生物制剂和资源核心提供的生物样品数据。综合系统生物学核心 将为项目和核心、核心人员之间的交叉授粉提供一个天然的基础 与所有项目调查员和核心总监合作。

PROJECT SUMMARY/ABSTRACT The Integrative Systems Biology Core will interact with all investigators to develop and apply appropriate analysis methods and designs to most efficiently achieve project goals. We will ensure that the experimental data is analyzed appropriately to test the hypotheses relevant to each project. In addition, the Integrative Systems Biology Core will provide infrastructure and oversight for secure management of all study data, working closely with the Bioreagents & Resource Core to facilitate accuracy and completeness of datasets for all projects and investigators. Our specific aims are: (1) To integrate cutting-edge analytic approaches in the design, analysis, and interpretation of experimental studies across projects in our program; and (2) To provide secure and accessible database systems and computational infrastructure to facilitate reliable and reproducible analyses conducted by all program investigators. The Integrative Systems Biology Core leverages faculty and resources in the Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine and the Duke Molecular Physiology Institute. Dr. Thomas LaFramboise will direct the Core, with Dr. Simon Gregory as co-director. The Integrative Systems Biology Core will serve as a centralized resource for all personnel, including the leaders of the three research projects and the Bioreagents & Resource Core. The Core will assist investigators with all facets of design, computational analysis and interpretation. Established as well as novel tailored analytic methods are available to promote scientific discovery for investigators within the Core. Core personnel will interact with investigators in all stages of research, from data management, data analysis, interpretation, writing scientific manuscripts and grants, to dissemination of results. The Core will also facilitate access to secure and accessible database systems, facilitating analysis, discovery and collaboration. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with biospecimen data as provided by the Bioreagents & Resource Core. The Integrative Systems Biology Core will provide a natural foundation for cross-pollination among the projects and Cores, the Core personnel collaborating with all project investigators and Core directors.