Administrative Core

项目总结/摘要 UCSF脑肿瘤孢子有三个总体的具体目标：1）确定新的免疫甲基组学- 有助于胶质瘤患者生存、诊断和治疗反应的生物标志物; 2） 开发非侵入性成像模式，可以确定IDH突变型胶质瘤患者对治疗的反应; 和3）开发使用自体T淋巴细胞的新型过继转移疗法，使我们能够克服 免疫治疗面临的挑战UCSF脑肿瘤孢子的管理核心一直是 成立的目的是监督UCSF脑肿瘤孢子的活动，并提供财政管理， 行政支持，以及研究人员可以交流和互动的框架。具体 SPORE管理核心的目标是：1）评估研究进展。行政核心，通过 SPORE执行委员会、SPORE指导委员会和SPORE外部咨询委员会， 将负责评估项目的进展情况，并就是否继续或 更换项目。2)提供财务管理。行政核心将从 SPORE奖，职业提升和发展研究计划，SPORE补充奖， 以及机构提供的自由支配资金。行政核心还将负责及时 向项目负责人和SPORE PI/co-PI提交财务报告。3)提供行政支持。的 行政核心将负责SPORE的日常运作，编写SPORE相关 手稿，以及与NIH的通信。4)促进SPORE调查人员之间的沟通 以及SPORE和外部实体之间的关系。行政核心将负责安排所有 会议，研讨会系列，和务虚会，并分发通知，邀请参加职业提升 计划和发展研究计划。行政核心还促进了沟通 与NIH和NIH资助的实体和脑肿瘤患者社区合作。5)协助遵守。的 行政核心将负责确保所有组成部分的合规性和科学完整性。 孢子。管理核心将由SPORE中的所有项目、项目群和核心使用。

Project Summary/Abstract The UCSF Brain Tumor SPORE has three overall specific objectives: 1) to identify novel immunomethylomics- based biomarkers that contribute to the survival, diagnosis, and therapy response in glioma patients; 2) to develop noninvasive imaging modalities that can define response to therapy in patients with IDH-mutant glioma; and 3) to develop novel adoptive transfer therapy using autologous T lymphocytes that allow us to overcome the current challenges for immunotherapy. The Administrative Core of the UCSF Brain Tumor SPORE has been established to supervise the activities of the UCSF Brain Tumor SPORE and to provide fiscal management, administrative support, and the framework by which researchers can communicate and interact. The specific aims of the SPORE Administrative Core are: 1) To evaluate research progress. The Administrative Core, through the SPORE Executive Committee, the SPORE Steering Committee, and the SPORE External Advisory Board, will be responsible for evaluating the progress of projects and making decisions regarding the continuation or replacement of projects. 2) To provide fiscal management. The Administrative Core will distribute funds from the SPORE Award, the Career Enhancement and Developmental Research Programs, SPORE Supplement Awards, and discretionary funds provided by the institution. The Administrative Core will also be responsible for timely financial reporting to Project Leaders and the SPORE PI/co-PIs. 3) To provide administrative support. The Administrative Core will be responsible for the daily operations of the SPORE, the preparation of SPORE-related manuscripts, and communications with the NIH. 4) To facilitate communication between SPORE investigators and between the SPORE and outside entities. The Administrative Core will be responsible for scheduling all meetings, seminar series, and retreats, and distributing notices inviting participation in the Career Enhancement Program and the Developmental Research Program. The Administrative Core also facilitates communication with NIH and NIH-funded entities and the brain tumor patient community. 5) To assist in compliance. The Administrative Core will be responsible for ensuring compliance and scientific integrity of all components of the SPORE. The Administrative Core will be used by all Projects, Programs, and Cores in the SPORE.