EMERGEncy ID Net Study

描述（由申请人提供）：EMERGEncy ID NET项目是美国11个地理位置不同的大学附属医院急诊科的哨点网络。该方案自1995年以来一直由疾病控制中心（CDC）资助，旨在通过评估疾病流行情况、风险因素和急诊部门不同人群中来自社区的急性症状的管理实践，解决新发传染病的威胁。EMERGEncy ID NET进行了几项前瞻性调查，最近针对急性肾盂肾炎患者的尿路病原菌抗菌药物耐药性和预后；特异性宿主基因对感染的反应；急诊医生对天花疫苗接种的态度和对生物恐怖威胁风险的感知；耐甲氧西林金黄色葡萄球菌（MRSA）在皮肤和软组织感染患者中的患病率。紧急ID NET项目的具体目标是继续与疾病预防控制中心合作，对美国出现的各种新感染进行持续调查。这将通过：1)识别急诊科患者中的新发感染；2)制定研究目标和材料；3)获得人体受试者保护委员会的必要批准进行研究；4)通过对急诊科患者的入组和随访来实施研究；5)管理收集到的数据；6)从研究中得出结果，并在同行评审的出版物和科学会议上报告我们的发现。在过去的十年里，紧急ID NET项目的成就证明了它有能力快速解决各种紧急的公共卫生传染病问题，并有效地将调查结果传播给传染病、公共卫生、急诊医生和公众。

DESCRIPTION (provided by applicant): The EMERGEncy ID NET program is a sentinel network of 11 geographically-diverse, university-affiliated hospital emergency departments in the United States. This program, which has been funded by the Centers for Disease Control (CDC) since 1995, was established to address the threat of emerging infectious diseases by assessing disease prevalence, risk factors, and management practices for acute presentations from the community among a diverse population presenting to emergency departments. EMERGEncy ID NET has prospectively conducted several investigations, most recently addressing uropathogen antimicrobial resistance and outcomes among patients with acute pyelonephritis; specific host gene responses to infections; emergency physicians' (EPs) attitudes towards smallpox vaccination and perceived risk of a bioterrorist threat; and the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) among patients with skin and soft tissue infections. The specific aim for the EMERGEncy ID NET program is to continue collaboration with the CDC to conduct ongoing investigations of various emerging infections in the United States. This will be accomplished by: 1) identifying emerging infections among emergency department patients; 2) developing study objectives and materials; 3) obtaining necessary approvals to conduct the research from Human Subject Protection Committees; 4) implementing the studies through enrollment and follow-up of emergency department patients; 5) managing data collected; 6) generating results from studies and reporting our findings in peer-reviewed publications and at scientific conferences. The accomplishments of the EMERGEncy ID NET program over the past 10 years demonstrate its capability to rapidly address a variety of urgent public health infectious disease problems and propagate the results of investigations effectively to infectious diseases, public health, and emergency medicine Practitioners, and to the public.