Genomics Alcohol Research Core

描述(由申请人提供)：以下资助申请是为了响应RFA-OD-09-005(恢复法案有限竞争：支持新教师招聘以通过生物医学研究核心中心加强研究资源[P30])而提交的。我们相信，该应用程序是对RFA的响应，因为我们寻求招聘，提供适当的启动方案，并为新独立的研究人员开发试点研究项目，目标是扩大和扩大OHSU的多学科研究人员社区，专注于与NIH相关的生物医学研究领域。本P30侧重于生物信息学核心，目标是招募对酒精和药物滥用感兴趣的个人(S)，以及对老鼠和非人类灵长类基因组学感兴趣的人。对酒精和药物滥用的重视与申请部门-行为神经科学的兴趣和资助组合一致。因此，我们认为申请最好是针对国家酒精滥用和酒精中毒研究所(NIAAA)。该应用程序的主要合作伙伴俄勒冈州国家灵长类动物研究中心(ONPRC)支持这种联合；在此，我们注意到最近联合聘请了凯西·格兰特博士(Behavial NeuroScience和ONPRC)，她是酒精滥用的灵长类动物模型的领先专家，也是该应用程序的合作者。然而，我们(行为神经科学和ONPRC)认为通过P30机制招募的个体(S)在开发OHSU的生物信息资源方面也有更大的作用。P30的大部分资金将用于帮助招聘初级教员，并开发一个试点研究计划。成功的申请者(S)将被任命为行为神经科学系(终身教职)的助理教授和ONPRC的工作人员科学家，同时还将被任命为分子和医学遗传学、医学信息学和临床流行病学系的联合教授。在核心的职位的成功申请者(S)将是个人(S)，在我们称之为“系统生物信息学”的领域拥有专业知识。使用这一术语的目的是，我们将招聘一名不仅具有有效利用mRNAseq或Chipseq等新兴技术的分析技能，而且对解决与中心相关的问题感兴趣的人。 公共卫生相关性：由P30机制支持的核心中心将用于招聘新的教员，从生物学角度研究酒精滥用和酒精中毒。这项研究首先将使用复杂的分析方法来研究受长期酒精暴露影响的大脑和其他组织中的基因表达。其目的是检测潜在的病理机制。

DESCRIPTION (provided by applicant): The following grant application is submitted in response to RFA-OD-09-005 (Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers [P30]). We believe that the application is responsive to the RFA In that we seek to hire, provide appropriate start-up packages and develop pilot research projects for newly-independent investigators, with the goal of augmenting and expanding OHSU's community of multidisciplinary researchers focusing on areas of biomedical research relevant to NIH. This P30 focuses on a Bioinformatics Core with the goal of recruiting individual(s) with interests in alcohol and drug abuse coupled with interests in mouse and non-human primate genomics. The emphasis on alcohol and drug abuse aligns with the interests and grant portfolio of the applicant department - Behavioral Neuroscience. Thus, we feel the application is best directed to the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The primary partner in this application, the Oregon National Primate Research Center (ONPRC) supports this alignment; here we note the relatively recent joint hiring (Behavioral Neuroscience and the ONPRC) of Dr Kathy Grant, a leading expert on primate models of alcohol abuse and a collaborator on this application. However, we (Behavioral Neuroscience and the ONPRC) view the indlvidual(s) recruited through the P30 mechanism as also having a larger role in developing bioinformatic resources at OHSU. The bulk of the P30 funding will be used to help recruit junior faculty and to develop a pilot research program. The successful applicant(s) will be appointed as an Assistant Professor in the Department of Behavioral Neuroscience (tenure track) and as a Staff Scientist at the ONPRC, with joint appointments in the Departments of Molecular & Medical Genetics and Medical Informatics and Clinical Epidemiology. The successful applicant(s) for the position within the Core will be individual(s) with expertise in a field we have termed "systems bioinformatics". The intent of using this term is that we will recruit an individual not only with the analytical skills to effectively utilize emerging technologies such as mRNAseq or ChiPseq but also with interests in solving problems related to the Center. PUBLIC HEALTH RELEVANCE: The Core Center supported by the P30 mechanism will be used to recruit new faculty to study from a biological perspective, alcohol abuse and alcoholism. The research will involve initially the use of sophisticated analytical approaches to study gene expression in brain and other tissues affected by chronic alcohol exposure. The goal is to detect the underlying pathological mechanisms.