Muscular Dystrophy Center Core Laboratories

描述（由申请人提供）：明尼苏达大学肌肉萎缩中心（UMN-MDCenter）自成立以来，在肌肉生物学和疾病的基础、临床和转化研究方面的合作不断扩大。MDCenter的成功最近帮助招募了几位杰出的肌肉研究人员到明尼苏达州，利用现有的力量创建了一个独特的多方面的项目，专注于了解肌肉和治疗肌肉疾病。为了最大限度地扩大MDCenter的互动，协作和生产力，我们正在申请NIAMS核心中心支持，具体目标如下：1)核心B：加强和增加研究核心的可及性，为肌肉研究者提供临床标本，并使用clia认证的肌肉活检实验室通过全面的组织学和免疫染色方法表征人类和动物肌肉。2)核心C：加强和扩大肌肉研究人员的小鼠肌肉萎缩模型库，这与我们中心在分子，细胞和整个组织水平上表征人类和动物肌肉力量产生的独特能力相结合。3)核心A：为研究核心提供行政支持，并为新的独立研究者建立试点和可行性计划，这将加强和扩展现有的医学中心本科生，研究生和博士后培训生项目。4)提高机构、区域和国家对UMN-MDCenter和CCMBM的认识，以加强提供与该计划潜力相称的机构资源。

DESCRIPTION (provided by applicant): The University of Minnesota Muscular Dystrophy Center (UMN-MDCenter) has grown in scope and breadth since being organized to improve collaboration in basic, clinical and translational investigation of muscle biology and disease. Success of the MDCenter has recently helped recruit several prominent muscle investigators to Minnesota, capitalizing on existing strength to create what is now a unique multifaceted program focused on understanding muscle and treating muscle disease. To maximize interaction, collaboration and productivity of the expanding MDCenter, we are applying for NIAMS Core Center support with the following specific aims: 1) Core B: To strengthen and increase accessibility of a research core that provides clinical specimens to muscle investigators, and uses the CLIA-certified muscle biopsy laboratory to characterize human and animal muscle with comprehensive histological and immunostaining methods. 2) Core C: To strengthen and expand a repository of murine muscular dystrophy models for muscle investigators, which is coupled with the unique ability of our Center to characterize human and animal muscle force generation at molecular, cellular and whole tissue levels. 3) Core A: To provide administrative support for the research cores, and to establish a pilot and feasibility program for new independent investigators, which will strengthen and extend current MDCenter programs for undergraduate, graduate and post-doctoral trainees. 4) To increase institutional, regional and national awareness of UMN-MDCenter and CCMBM to enhance provision of institutional resources commensurate with the potential of this program.