Integrative Biology Core

WF OAIC综合生物学核心(IBC)对WF OAIC的总体使命和目标至关重要。它 在识别和整合导致衰老相关残疾的生物因素方面起着至关重要的作用 流程。IBC在临床前动物之间翻译关于生物衰老的知识 模型和人类来发现和测试导致人类功能衰退的生物学因素。IBC提供了 测试与年龄相关的传统和新生物因素所需的物质支持和指导 功能衰退和残疾。在下一个周期中，我们将进一步提出IBC的主要假设：1) 综合生物过程影响衰老相关的身体功能丧失，以及2)治疗 这些生物过程的改变将减缓残疾的进展。 IBC工作背后的前提是：(A)特定的细胞、器官和系统过程在一个 影响衰老相关功能丧失的综合方式，以及(B)这些因素的治疗修饰 会减缓残疾的进展。 IBC的具体目标是：1)提供关键服务，促进对蜂窝的了解， 与衰老相关的身体功能下降背后的组织和系统生物学因素；2)促进 OAIC支持的老龄化综合研究中生物样品资源的获取和分布 数据库存储库(IASDR)，以有效地生成和测试新的假设；3)开发新的方法和 为OAIC调查人员扩展核心服务的协作。4)提供OAIC支持的教师和 学员对与衰老有关的身体机能下降的生物因素的指导和教育。 德尔博诺博士和贾斯蒂斯博士将共同领导IBC，该委员会使用最先进的细胞和分子技术 IBC调查人员和其他WFUSM核心实验室的集体实验室，以支持新的 研究主题与WF OAIC的目标一致，即整合影响身体功能的通路 寻求残疾治疗和预防的新办法“。 在第一年，IBC将提供物资、技术资源和咨询科学支持：2名飞行员(1 由一名REC学者领导)；2名REC学者；1个开发项目；以及通过添加以下内容来测试新假设 将在10个外部资助项目中评估生物学成果。核心为OAIC提供 尖端科学仪器和技术，以及翻译研究的专业知识广度 有效实现我们的目标所需的频谱，具有规模经济，并与 其他OAIC核心。

The WF OAIC Integrative Biology Core (IBC) is critical to the overall mission and goals of the WF OAIC. It plays an essential role in identifying and integrating biologic factors that contribute to aging-related disability processes. The IBC translates knowledge on biological aging translationally between preclinical animal models and humans to discover and test biological contributors to human functional decline. The IBC provides material support and guidance needed to test both traditional and novel biological factors in age-related functional decline and disability. In the next cycle, we will further the overarching IBC hypotheses that: 1) integrative biological processes influence aging-related loss of physical function, and 2) therapeutic modification of these biological processes will slow progression to disability. The premise behind the IBC’s work is that (a) specific cellular, organ, and systemic processes combine in an integrated manner to influence aging-related loss of function, and (b) therapeutic modification of these factors will slow progression to disability. The Specific Aims of the IBC are to: 1) Provide key services that advance the understanding of the cellular, tissue, and systemic biological factors underlying aging-related decline in physical function; 2) Facilitate acquisition and distribution of biospecimen resources in the OAIC-supported Integrated Aging Studies Databank Repository (IASDR) to efficiently generate and test novel hypotheses; 3) Develop new methods and collaborations that expand Core services for OAIC investigators. 4) Provide OAIC-supported faculty and trainees mentorship and education on biological factors underlying aging-related decline in physical function. Drs. Delbono and Justice will co-Lead the IBC, which uses state-of-the-art cellular and molecular techniques of the collective laboratories of IBC investigators and other WFUSM Core laboratories, to support novel research thematically aligned with the WF OAIC objective of “Integrating pathways affecting physical function for new approaches to disability treatment and prevention”. In Year 1 the IBC will provide supplies, technical resources, and consultative scientific support for: 2 pilots (1 led by a REC Scholar); 2 REC Scholars; 1 Development Project; and testing of new hypotheses by adding biological outcomes to be assessed in 10 Externally-supported Projects. The Core provides the OAIC with cutting-edge scientific instruments and technology, and breadth of expertise across the translational research spectrum required to accomplish our aims efficiently, with economy of scale, and in close coordination with the other OAIC cores.