Novel approaches to understanding mental disorder, substance abuse and HIV-risk a

描述（由申请人提供）：这份[修订的]R21申请寻求两年的支持，以开发最先进的科学方法，以解决有关无家可归妇女的现有研究中的四个重要差距：1)捕捉流动和难以接触的人口的情况多样性；2)增加我们对各种无家可归妇女的精神和物质使用障碍（特别是人格障碍）的理解；3)通过开发一种创新的事件历史日历方法，提高我们对无家可归者轨迹的理解；4)根据情况和走向无家可归的轨迹，增进对无家可归妇女的健康和艾滋病毒风险的了解。本研究将为多州纵向R01提供测量发展和初步研究，旨在提高我们对无家可归妇女的精神和物质使用障碍的理解，她们进出无家可归的运动，无家可归对妇女和未成年子女的影响，以及妇女的健康，艾滋病毒风险和艾滋病毒检测行为。这项计划中的纵向研究将集中在不断增长但人们对这个国家最脆弱的女性群体知之甚少的人群上。这项R21发展申请的具体目标是：1)制定和试行一项抽样计划，以更好地反映无家可归妇女的多样性；2)开发和试点一个创新的事件历史日历，用于无家可归的妇女；3)计划和试点轴1 （UM-CIDI）和轴2 （DIPD-IV）诊断访谈时间表，对无家可归妇女进行计算机辅助个人访谈；4)制定和规划妇女健康和艾滋病毒风险措施；5)在中西部两个城市的200名无家可归的妇女中试行这些措施。公共卫生相关性：这个[修订的]R21发展应用程序将为无家可归妇女的第一个多州纵向诊断研究奠定基础。它建立在十多年来努力接触无家可归人口的工作和之前对无家可归青少年的三年纵向诊断研究的基础上。这项申请将资助开发创新措施和抽样技术，专门针对这一研究不足的人口，并在中西部两个城市以200名无家可归妇女为样本进行措施试点。

DESCRIPTION (provided by applicant): This [revised] R21 application seeks two years of support to develop state-of-the-science methodologies to address four important gaps in existing research with homeless women: 1) capture the diversity of circumstances among a fluid and hard-to-access population; 2) increase our understanding of mental and substance use disorders (particularly personality disorders) across the diversity of homeless women; 3) improve our understanding trajectories to homelessness through development of an innovative event history calendar approach; and 4) advance knowledge of homeless women's health and HIV-risk by circumstance and trajectories to homelessness. This research will provide measurement development and preliminary studies for a multi-state longitudinal R01 designed to advance our understanding of mental and substance use disorders among homeless women, their movement into and out of homelessness, the consequences of homelessness for women and minor children in their custody, and women's health, HIV-risk, and HIV testing behaviors. The planned longitudinal research will focus on a growing but poorly understood population of the nation's most vulnerable women. The specific aims of this R21 developmental application are to 1) develop and pilot a sampling plan that will better reflect the diversity of homeless women; 2) develop and pilot an innovative events history calendar for use with homeless women; 3) program and pilot Axis 1 (UM-CIDI) and Axis II (DIPD-IV) diagnostic interview schedules for computer-assisted personal interviews with homeless women; 4) develop and program women's health and HIV-risk measures; and 5) pilot the measures with 200 homeless women in two Midwestern cities. PUBLIC HEALTH RELEVANCE: This [revised] R21 developmental application will set the stage for the first multi-state longitudinal diagnostic study of homeless women. It builds on more than a decade of work with hard to access homeless populations and a prior three-year longitudinal diagnostic study of homeless adolescents. This application will fund the development of innovative measures and sampling techniques specifically for this understudied population and for the piloting of measures with a sample of 200 homeless women in two Midwestern cities.