Alcohol abuse/dependence and its consequences for Indigenous adolescents

酒精滥用/依赖及其对土著青少年的后果

• 批准号: 8691614
• 负责人: LESLIE B WHITBECK
• 金额: $ 45.43万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8691614
• 关键词: Address; Adolescence; Adolescent; Adolescent Behavior; Affect; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohols; Attention; Basic Science; Behavior; Behavioral Symptoms; Biological; Characteristics; Communities; Comorbidity; Complex; Conduct Disorder; Data; Data Analyses; Data Collection; Data Reporting; Data Set; Dependence; Development; Developmental Diagnostic; Developmental Process; Diagnostic; Disease; Dysthymic Disorder; Educational workshop; Family Process; Foundations; Frequencies; Funding; Future; Generalized Anxiety Disorder; Goals; Grant; Healed; Indigenous; Intervention; Left; Measures; Mediating; Mediator of activation protein; Mental disorders; National Institute of Drug Abuse; National Institute of Mental Health; Ojibwe; Oppositional Defiant Disorder; Outcome; Ownership; Parents; Pathway interactions; Population; Prevention; Prevention program; Process; Reporter; Reporting; Research; Research Personnel; Reservations; Risk; Running; Science; Staging; State Government; Substance Use Disorder; Symptoms; Time; Translating; Translations; Trust; United States National Institutes of Health; Work; Writing; aged; alcohol epidemiology; alcohol prevention; anti social; base; community based participatory research; design; early adolescence; emerging adult; empowered; expiration; externalizing behavior; healing; high risk; innovation; intergenerational; meetings; programs; public health relevance; public policy on alcohol; response; single episode major depressive disorder; technical writing; underage drinking; young adult

DESCRIPTION (provided by applicant): This [is the second submission of our RO1 application] in response to the announcement: Secondary Analysis of Existing Alcohol Epidemiology Data (PA-08-167). With this application we seek funding to extend our community-based participatory research (CBPR) with Ojibwe people on four U.S. reservations and four Canadian reserves for three additional years to work with our community partners to complete data analysis focusing on the development of alcohol abuse and dependence disorders among Ojibwe adolescents. The proposed state-of-the- science longitudinal analyses of a one-of-a-kind eight-year panel study of adolescents (aged 10 - 12 years at Wave 1 and 17 - 19 years at Wave 8) will advance our understanding of developmental processes regarding alcohol use and abuse among a high-risk population, inform innovative, empirically driven, cultural interventions and fulfill the CBPR obligation of leaving something useful behind after more than eight years of community involvement in collecting this important information. The program of research on which this application is based was a lagged sequential design funded by NIDA and NIMH. DA13580 was initially funded 9/30/2000 and renewed via a competitive continuation 9/03/2005. MH067281 was initially funded 7/01/2002 and competitively renewed 7/01/07. The work comprises the only long-term developmental, diagnostic study of Indigenous adolescents and their parents/caretakers to date. Funding for DA13580 runs out 6/30/2010 and with it our ability to maintain our community partnerships. The specific aims of the original research application DA13580 have been accomplished but there remains an enormous amount of analytic work with an extremely rich and complex data set focusing specifically on onset of alcohol use and abuse and its consequences from early to late adolescence. The analytic plan will address eight foci: 1) the emergence of alcohol use, abuse, and dependence across time; 2) the relationship between internalizing and externalizing behaviors on alcohol use and abuse; 3) protective factors against adolescent alcohol use and abuse; 4) the effects of group membership on alcohol outcomes; 5) co morbidities of alcohol abuse/dependence with other psychiatric disorders such as major depressive episode, generalized anxiety disorder, and conduct disorder; 6) the timing of behaviors related to alcohol use in relation to one another, 7) potential mediators between alcohol use and antisocial behaviors; and 8) the effects of community characteristics on alcohol use/abuse. This is the only longitudinal, diagnostic data set of which we are aware that follows Indigenous young people through their entire adolescence. The eight-wave data set has four DISC-R diagnostic data points: Wave 1 (ages 10 - 12 years; parent/caretaker and adolescent reports); Wave 4 (ages 13 - 15 years; parent/caretaker and adolescent reports); Wave 6 (ages 15 - 17 years, adolescent reports); Wave 8 (ages 17 - 19 years, adolescent reports). In addition to four diagnostic data points, the data is replete with symptom and behavioral scales, multiple reporter (parent/caretaker and adolescent) measures of parent/caretaker-adolescent interactions and adolescent behaviors, and community measures. The proposed analyses provide a unique opportunity to trace the early emergence of alcohol use and its developmental consequences, including the onset of alcohol abuse and dependence disorders.

描述（由申请人提供）：这是对公告的响应：现有酒精流行病学数据的二次分析（PA-08-167）。通过此应用程序，我们寻求资金来扩展我们的基于社区的参与性研究（CBPR）与Ojibwe人民进行四个美国预订和四个加拿大储备金的另外三年，以与我们的社区合作伙伴合作，以完成有关Ojibwe青少年中酒精滥用和依赖性障碍的发展的数据分析。一项独一无二的八年级小组研究的拟议的最先进的纵向分析（在第8波第1浪和17-17岁之间的10至12岁年龄在第8波第8波的年龄）将提高我们对饮酒过程的理解，并在经验驱动的八年中涉及八年来，涉及八年来，涉及八年来，涉及CBP，而涉及CB Pr的有效性。重要信息。该应用程序所基于的研究计划是由NIDA和NIMH资助的滞后顺序设计。 DA13580最初由2000年9月30日资助，并通过2005年9月3日的竞争延续进行续签。 MH067281最初由2002年7月1日资助，并竞争性续签7/01/07。这项工作是迄今为止对土著青少年及其父母/看护者的唯一长期发展，诊断研究。 DA13580的资金为6/30/2010，并具有维持社区合作伙伴关系的能力。原始研究应用程序DA13580的具体目的已经完成，但仍有大量的分析工作，非常丰富且复杂的数据集，专门针对酒精使用和滥用的发作及其从青春期早期至后期的后果。分析计划将解决八个焦点：1）随着时间的流逝，饮酒，滥用和依赖的出现； 2）内在化与饮酒和滥用行为的外在行为之间的关系； 3）防止青少年饮酒和滥用的保护因素； 4）小组成员资格对酒精结果的影响； 5）与其他精神疾病（例如重大抑郁事件，广泛焦虑症和行为障碍）的酗酒/依赖性疾病的病态性； 6）与饮酒有关的行为时机相对于彼此而言，7）饮酒和反社会行为之间的潜在介体； 8）社区特征对酒精使用/滥用的影响。这是唯一的纵向诊断数据集，我们知道，在整个青春期中，它跟随土著年轻人。八波数据集具有四个Disc-R诊断数据点：波1（10-12岁；父母/看守和青少年报告）；第4波（13-15岁；父母/看守和青少年报告）；第6波（15至17岁，青少年报告）；第8波（年龄17至19岁，青少年报告）。除了四个诊断数据点外，数据还充满了症状和行为量表，多个记者（父母/看护人和青少年）的父母/看护人与青少年互动以及青少年行为以及社区措施的度量。拟议的分析为追踪酒精使用及其发育后果的早期出现提供了独特的机会，包括酒精滥用和依赖障碍的发作。