Investigating the role of altered lung microbiome in fueling Th17 mediated airway inflammation in COPD among HIV-infected individual

摘要 研究支气管镜检查使研究人员能够接触到远端呼吸道样本，产生了有价值的 关于远端呼吸道炎症过程的信息。然而，这些程序构成了一个重要的 研究参与者的负担，风险和收益之间只有一条细线。在乌干达，我们缺乏国家政策。 关于选择性支气管镜检查的研究。此外，社区参与是伦理研究的一个关键方面 在乌干达的大多数支气管镜检查中，并不是常规进行的。因此，迫切需要 探索潜在参与者对支气管镜检查研究的理解，什么会促使他们参与 正在研究中的支气管镜检查及其关注的问题，以便为未来的临床研究提供同意的过程 和国家政策。在农村正在进行的艾滋病毒-BAL研究(R21研究)的研究框架内 乌干达的Nakaseke区，旨在调查肺部微生物群和免疫之间的关联 在乌干达HIV队列中，HIV感染者与COPD患者的远端呼吸道的分布，我们建议(I) 探讨乌干达农村地区未来研究支气管镜检查参与者的需求和关切 社区；(2)制定和整合促进社区参与性的社区参与计划 支气管镜检查研究和(Iii)在研究中纳入有指导的非学位生物伦理学培训 乌干达的支气管镜检查。随着我们计划的成功执行，我们希望将研究设计、信息 乌干达支气管镜检查研究中的提供和同意程序。最终，我们希望通知国家 乌干达支气管镜检查研究指南。

Abstract Research bronchoscopies have enabled access to distal airway samples by investigators, yielding valuable information about the inflammatory processes in distal airways. Such procedures, however, pose a significant burden on research participants, with a thin line between risk and benefit. In Uganda, we lack national policies on elective research bronchoscopy. Furthermore, community engagement, a critical aspect of ethical research conduct, is not routinely done in most bronchoscopy studies in Uganda. Therefore, there is a pressing need to explore potential participants’ understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns in order to inform consenting processes for future clinical studies and national policy. Within the research framework of the ongoing HIV-BAL study (R21 study) in the rural Nakaseke district of Uganda, aimed at investigating the association between lung microbiome and immune profile in the distal airways of HIV-infected individuals with COPD in a Ugandan HIV cohort, we propose to (i) explore the needs and concerns of prospective research bronchoscopy participants in rural Ugandan communities; (ii) develop and integrate a community engagement plan promoting community-based participatory research in bronchoscopy studies and (iii) integrate a mentored non-degree bioethics training in research bronchoscopy in Uganda. With the successful execution of our plan, we hope to inform study design, information provision, and consenting processes in bronchoscopy studies in Uganda. Ultimately, we hope to inform national guidelines governing research bronchoscopies in Uganda.