Cortical neuromodulatory mechanisms underlying adaptation and plasticity

项目总结 在我们之前的研究中，我们建立了突触锌作为突触的强大神经调节剂。 传递、突触可塑性和声音处理。根据这些发现和我们的初步结果，我们 提出皮质突触锌是皮质适应和可塑性(恢复)的重要神经调节剂 噪音创伤后(外周损伤)。也就是说，我们计划回答两个主要问题：1)什么是细胞- 不同背景下皮层适应的类型特异性锌能神经调节机制 可靠的统计数据吗？2)细胞类型特异的锌能神经调节机制如何影响大脑皮层 以及外周损伤后的知觉恢复？回答这些问题将把这个领域推向一个新的 对正常和病理感觉过程中皮质神经调节机制的理解水平 加工，并创建了一个新的框架，以接近和解释皮质适应和可塑性。 重要的是，我们建议的研究有可能强调增强听力的新策略 听力损失，以及减轻与外周后适应不良的中枢可塑性相关的障碍 损害，如听力过敏症和耳鸣

PROJECT SUMMARY During our previous studies, we established synaptic zinc as a powerful neuromodulator of synaptic transmission, synaptic plasticity, and sound processing. Based on these findings and our preliminary results, we propose that cortical synaptic zinc is a crucial neuromodulator for cortical adaptation and plasticity (recovery) after noise trauma (peripheral damage). Namely, we plan to answer two main questions: 1) What are the cell- type-specific zincergic neuromodulatory mechanisms underlying cortical adaptation to different background sound statistics? And 2) How do cell-type-specific zincergic neuromodulatory mechanisms contribute to cortical and perceptual recovery after peripheral damage? Answering these questions will advance the field to a new level of understanding about cortical neuromodulatory mechanisms during normal and pathological sensory processing, and create a new framework for approaching and interpreting cortical adaptation and plasticity. Importantly, our proposed studies hold the potential to highlight novel strategies for enhancing hearing after hearing loss, and for mitigating disorders that are associated with maladaptive central plasticity after peripheral damage, such as hyperacusis and tinnitus