Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University of Missouri Regional Biocontainment Laboratory

整体项目总结 大学NIH/NIAID高优先级病原体研究的资源和劳动力培养 密苏里州地区生物遏制实验室 密苏里大学区域生物遏制实验室(RBL)于2009年投入1800万美元， 12,377个NSF BSL-3/ABSL-3设施。在其13年的运营中，RBL后来将MU命名为 传染病研究实验室(LIDR)一直是更广泛的传染病的核心 密苏里大学研究界，在招聘中收到了强有力的机构承诺 和维持世界一流的管理RBL/LIDR和开展HIGH研究的师资队伍 优先病原体。LIDR运营共享的研究资源，包括最先进的设备和 微生物学、空气生物学、免疫学和动物模型核心设施方面的专业服务 研究人员在校园以及更广泛的区域和国家社区的需求。教职员工和 LIDR的专业工作人员是NIH/NIAID RBL-NBL网络的一部分，通过协作互动 促进最佳做法和知识的共享，在实现我们的集体生物防御和 新发传染病研究议程。在COVID大流行期间，MU LIDR及其RBL 和NBL合作伙伴，领导对大流行的反应，并致力于加强大流行 通过提供BSL-3/ABSL-3培训、专业人员和研究服务，为国家做好准备 允许在所有领域作出快速反应，包括发展动物模型和评估许多 治疗、消毒剂和疫苗平台，以抗击大流行。当前的长期目标 申请是为了继续领导开发新的医学对策，以抗击 不断出现和不断变化的新出现和再次出现的传染病的威胁，同时培训 下一代科学家和生物遏制专业人员的优秀干部。建议的目标是 设施管理、维护和运营、BSL3实践和生物遏制研究的核心 支持服务旨在教育和培训下一代科学家和生物遏制专业人员 生物防御和新出现的传染病，并促进和加强新的开发 预防和治疗由自然感染的高后果病原体引起的感染的方法 或故意传播对公共卫生和国家安全构成威胁。为了实现这些目标，拟议的 CORE将在MU更广泛的传染病社区和NIH/NIAID RBL-NBL网络中工作，以 提高研究效率和发现，并继续分享信息和最佳做法 以满足NIH/NIAID在生物防御和新出现的传染病方面不断变化的优先事项和需求。

Overall Project Summary Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University of Missouri Regional Biocontainment Laboratory The University of Missouri Regional Biocontainment Laboratory (RBL) was commissioned in 2009 as an $18M, 12,377 NSF BSL-3/ABSL-3 facility. During its thirteen years of operation, the RBL, since named the MU Laboratory for Infectious Disease Research (LIDR) has been a centerpiece of the broader infectious disease research community at the University of Missouri, receiving strong institutional commitment in the recruitment and sustainment of world-class faculty for management of the RBL/LIDR and for conducting research on high priority pathogens. The LIDR operates shared research resources, including state-of-the-art equipment and professional services in microbiology, aerobiology, immunology, and animal model core facilities that serve the needs of researchers on campus and in the broader regional and national communities. The faculty and professional staff of the LIDR are part of the NIH/NIAID RBL-NBL network, with collaborative interactions that facilitate sharing of best practices and knowledge, providing synergy in achieving our collective biodefense and emerging infectious disease research agenda. During the COVID pandemic, the MU LIDR, along with its RBL and NBL partners, led the response to the pandemic and are committed to strengthening pandemic preparedness of the nation, by providing BSL-3/ABSL-3 training, professional staff, and research services that allow for rapid responses in all areas, including development of animal models and the evaluation of numerous treatments, disinfectants, and vaccine platforms to combat the pandemic. The long-term goal of the present application is to sustain a leading effort for development of novel medical countermeasures for combating the ever present and changing threats of emerging and re-emerging infectious diseases, while training an outstanding cadre of next generation scientists and professionals in biocontainment. The goals of the proposed cores in Facility Management, Maintenance and Operations, BSL3 Practices, and Biocontainment Research Support Services are to educate and train the next generation of scientists and biocontainment professionals in biodefense and emerging infectious diseases, and to facilitate and enhance the development of novel approaches for prevention and treatment of infections caused by high consequence pathogens whose natural or deliberate transmission pose a threat to public health and national security. Towards these goals, the proposed Cores will work within the broader infectious disease community at MU and the NIH/NIAID RBL-NBL network for enhancement of research productivity and discovery, and continued sharing of information and best practices in order to meet the changing priorities and needs of NIH/NIAID for biodefense and emerging infectious diseases.