Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC-IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention

项目总结/摘要 包括新发传染病在内的公共卫生威胁突出表明，需要加强 监测和实验室系统，以更快、更智能地应对疫情。泰国外交部 公共卫生部医学科学部（DMSc）疾病控制中心（DDC）已 与朱拉隆功大学和泰国红十字会合作， 研究和其他新发地方性传染病的监测、预防和控制。这项建议 将启动“传染病控制综合公共卫生和学术合作”（iPHAC- 国际数据公司）：“在大流行病防备和青少年艾滋病毒预防方面实施”一个健康“办法”， 来自DDC、DMSc、CU和TRC的传染病控制研究人员之间的协作嵌套网络， 以及美国和法国的EID专家。iPHAC-IDC将建立一个综合和可持续的 为泰国未来的疾病爆发做好准备。我们将进行研究，以1）开发和 实施下一代公共卫生监测方法，通过使用PCR，下一代 测序和多重血清学检测，以识别新型病毒，表征新罕见病毒的基因组， 地方病病毒株、EID和AMR。这些基因组数据将与临床和 流行病学数据，以创建病原体基因组监测平台。此外，基因组数学 将开发各种模型并将其嵌入该平台，以便进行实时分析。1次健康监测 包括废水和空气在内的环境中的方法，以及SARS-CoV-2逆转野生动物中的人畜共患病 将被追究。2)开发和实施全球健康学院的GLLP课程， 朱拉隆功大学医学院GLLP课程，分两门模式课程;必修课 医学科学计划的一个健康分支课程和其他研究生的选修课程 学生和终身学习平台，所有参与者都可以选择保留学分以进一步索赔 在进入CU之后。3)在政府医院发展以青少年为中心的预防爱滋病服务模式 建立以青年为中心的诊所网络，提供全面的艾滋病毒教育和预防， 利用社交网络策略进行暴露前预防， 基因组学抗性监测。 这项研究将促进我们对EIDS和地方病风险的认识，并加强对- 提高国家公共卫生研究能力，促进大流行病实验室工作人员队伍的发展 预防艾滋病毒和青少年艾滋病。

PROJECT SUMMARY/ABSTRACT Public health threats including emerging infectious diseases (EIDs) have highlighted the need for strengthening surveillance and laboratory systems for faster and smarter outbreak response. The Thai Department of Diseases Control (DDC), the Department of Medical Sciences (DMSc), Ministry of Public Health have collaboratively worked with Chulalongkorn University (CU) and the Thai Red Cross Society (TRC) on HIV research and other emerging endemic infectious disease surveillance, prevention, and control. This proposal will launch the “Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC- IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention”, a collaborative nested network among infectious disease control researchers from DDC, DMSc, CU and TRC, as well as EID experts in the USA and France. The iPHAC-IDC will establish an integrated and sustainable network to prepare for future disease outbreaks in Thailand. We will conduct research to 1) Develop and implement the NextGen Public Health Surveillance Approaches by using the PCR, next-generation sequencing, and multiplex serology assays to identify novel viruses, characterize the genomes of new-rare viral strains of endemic diseases, EIDs, and AMR. These genomic data will be integrated with clinical and epidemiologic data to create a pathogen genomic surveillance platform. In addition, genomic-mathematic models will be developed and embedded in the platform for real-time analysis. One Health surveillance approaches in the environment, including wastewater and air, and SARS-CoV-2 reverse zoonoses in wildlife will be pursued. 2) Develop and implement the GLLP curriculum at the School of Global Health by creating a GLLP curriculum at the Faculty of Medicine, Chulalongkorn University, in two pattern courses; A mandatory course in the One Health Branch of the Medical Sciences program and an elective course for other graduate students and a lifelong learning platform for all participants with an option to keep the credits for further claims after enrollment to CU. 3) Develop a youth-focused HIV prevention service model in the government hospital network by establishing youth-focused clinics that provide comprehensive HIV education and prevention with pre-exposure prophylaxis leveraging social network strategies, and improving gonorrhea antimicrobial genomics resistance surveillance. This research will advance our understanding of the risk of EIDs and endemic diseases and strengthen in- country public health research capacity and promote laboratory workforce development for pandemic preparedness and adolescent HIV prevention.