ENVIONMENTAL AGENTS IN THE INDUCTION OF AUTOIMMUNITY

描述：这项建议的主要目标是研究 环境毒物对环境的影响 抗雌激素的特性：(1)自身免疫性狼疮病程 狼疮小鼠的品系，(2)糖尿病易感鼠的自身免疫过程 和抗糖尿病小鼠，以及(3)这些药物诱导 两种正常品系小鼠的自身免疫性肾病。这些目标 将通过给予雌激素和抗雌激素药物来解决 然后评估对产生自身抗体的影响，B 肾脏和肾脏自身免疫病理的细胞增殖和发展 胰腺。

DESCRIPTION: The primary objective of this proposal is to examine the effect of environmental toxicants that possess either estrogenic or antiestrogenic properties on: (1) the course of lupus in one autoimmune strain of mice with lupus, (2) the course of autoimmunity in diabetes-prone and diabetes-resistant mice, and (3) the ability of these agents to induce autoimmune renal disease in two normal strains of mice. These objectives will be addressed by administering estrogenic and antiestrogenic agents to mice, and then evaluating the effect on the production of autoantibodies, B cell proliferation and development of autoimmune pathology in the kidney and pancreas.