CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。罗彻斯特大学临床和转化科学研究所（UR CTSI）将被创建为临床和转化科学的学术中心，提供集中的综合基础设施。在一个管理体系下，大学CTSI项目主任有权管理与CTSI相关的空间、教员、预算和其他资源，并且目前GCRC的大部分预算分配给CTSI关键职能部门以支持这些职能部门，我们计划将临床科学和转化科学这两个不同的研究领域转变为一个单一的新学科。本学科的目标包括创造诊断、预防和治疗人类疾病的新知识和新技术，并建立促进其在社区临床实践中的应用的环境。为了实现这些目标，我们提出了具体的目标，包括：新颖的方法；试验研究;升级生物医学信息学、流行病学、研究设计、伦理和监管支持；社区参与;新技术和资源核心；新的教育和培训项目；纽约州北部财团；以及对绩效结果的严格评估和衡量。在此之前，UR CTSI的战略规划已经进行了几年。机构支持的证据包括承诺新建15万平方英尺的办公楼。ft.临床和转化科学大楼（CTSB），在这里，进行临床和转化研究的教师将与现有和新的学位授予项目的学生和学员聚集在一起，支持监管和行政职能，以及在生物统计学、流行病学和生物医学信息学等合作学科工作的教师。大学CTSI主任和联席主任将整合CTSB的临床和转化科学功能，以及其他校区的功能，如功能基因组学、其他转化资源和普通临床研究中心（GCRC）。作为综合研究中心的一个组成部分，粤港澳中心将搬入一个新装修的10,500平方英尺的设施，与综合研究中心隔街相望，加强功能和主题通道。此外，UR CTSI将与当地社区团体（学校系统、宗教团体、企业、基金会）和纽约州北部的其他机构建立双向协同作用。此外，UR CTSI将使跨学科和跨机构的数据共享成为可能，同时确保人类受试者的隐私和机密性。总之，通过合并和整合新设施，加强基础设施，社区和全州范围的合作伙伴关系，现有研究和培训的坚实基础，以及从根本上重组的行政结构，CTSI将改变临床和转化科学的行为，并在全国范围内为这一新学科的建立做出贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The University of Rochester Clinical and Translational Science Institute (UR CTSI) will be created as the academic home for clinical and translational science, providing a centralized, integrated infrastructure. Under a system of governance in which the UR CTSI Program Director has authority over space, faculty, budgets, and other resources related to the CTSI, and in which much of the current GCRC budget is distributed to CTSI Key Functions in support of these functions, we plan to transform the two distinct research fields of clinical and translational science into a single new discipline. The goals of this discipline nclude the creation of new knowledge and techniques to diagnose, prevent and treat human disease, and he establishment of an environment that catalyzes their application to clinical practice in the community. To achieve these goals, we propose specific aims involving: novel methodologies; pilot studies; upgraded biomedical informatics, epidemiology, research design, ethics, and regulatory support; community engagement; new technology and resource cores; new educational and training programs; an Upstate New York Consortium; and rigorous evaluation and measurement of performance outcomes. Strategic planning for the UR CTSI has been underway for several years prior to this RFA. Evidence of institutional support includes commitment to a new 150,000 sq. ft. Clinical and Translational Science Building (CTSB) in which faculty conducting clinical and translational research will be brought together with students and trainees in existing and new degree-granting programs, with supporting regulatory and administrative functions, and with faculty working in collaborative disciplines such as biostatistics, epidemiology, and biomedical nformatics. The Director and Co-Directors of the UR CTSI will integrate the clinical and translational science functions contained in the CTSB with those functions located at other campus locations, such as functional genomics, other translational resources, and the General Clinical Research Center (GCRC). As an integral part of the CTSI, the GCRC will move into a newly-renovated 10,500 sq ft facility across the street from the CTSB, with enhanced functionality and subject access. As well, the UR CTSI will create two-way synergies with local community groups (school system, faith community, business, foundations) and with other Upstate New York institutions. Further, the UR CTSI will enable the sharing of data across disciplines and across institutions while assuring the privacy and confidentiality of human subjects. In summary, by coalescing and integrating new facilities with enhanced infrastructure, community and state-wide partnerships, a strong foundation of existing research and training, and a fundamentally reorganized administrative structure, the CTSI will transform the conduct of clinical and translational science at UR and contribute nationally to the forging of this new discipline.