Improving WNPRC Infrastructure to Support HIV/AIDS Research

描述(由申请人提供)：威斯康星州国家灵长类动物研究中心(WNPRC)支持一项积极的艾滋病毒/艾滋病研究计划，该计划由国家卫生研究院和私人实体提供超过800万美元的资金。WNPRC的研究人员用猿猴免疫缺陷病毒(SIV)感染印度血统的恒河猴和毛里求斯的食蟹猴，以研究艾滋病毒的发病机制和疫苗开发。目前，WNPRC将205只猕猴(153只恒河猴，52只食蟹猴)分配到20个不同的动物护理和使用方案涵盖的27个单独项目中，用于艾滋病毒/艾滋病研究。WNPRC的调查人员从该中心自己的无特定病原体(SPF)繁殖群体中获得用于艾滋病毒/艾滋病项目的猕猴。这项提议旨在获得资金，以当代移动式笼养取代SPF繁殖区老化的固定式笼养。该提案还寻求拨款，以扩大现有的流动笼子，以改善居住在WNPRC的SPF群体和感染SIV的猕猴的心理健康。最后，这项建议还寻求资金，以升级WNPRC感染SPF和SIV的猕猴住宅区的有形基础设施(如门、地板)。成功完成本提案中概述的目标将确保进行ZHIV/AIDS研究的WNPRC调查人员获得优质动物，并确保这些动物的心理健康得到保护。

DESCRIPTION (provided by applicant): The Wisconsin National Primate Research Center (WNPRC) supports an active HIV/AIDS research program with greater than $8,000,000 in funding from the National Institutes of Health and private entities. WNPRC investigators infect rhesus macaques of Indian ancestry and cynomolgus macaques of Mauritian origin with Simian Immunodeficiency Virus (SIV) to study HIV pathogenesis and vaccine development. Currently, 205 macaques (153 rhesuses, 52 cynomolgus) assigned to 27 individual projects covered by 20 different animal care and use protocols are utilized for HIV/AIDS research at the WNPRC. WNPRC investigators acquire macaques for HIV/AIDS projects from the Center's own Specific Pathogen Free (SPF) breeding colony. This proposal seeks to acquire funding to replace aging stationary caging in the SPF breeding area with contemporary mobile caging. The proposal also seeks funding to augment the existing mobile caging to improve the psychological well being of the SPF colony and the SIV-infected macaques housed at the WNPRC. Finally, this proposal also seeks funding to upgrade the physical infrastructure (e.g., doors, flooring) of the SPF and SIV-infected macaque housing areas of the WNPRC. Successful completion of the aims outlined in this proposal will ensure that WNPRC investigators performing ZHIV/AIDS research are provided with quality animals and that the psychological health of these animals is protected.