Renovating Existing SPF Macaque Housing Space for the WNPRC

描述（由申请人提供）：目前，威斯康星州国家灵长类动物研究中心的特定病原体无恒河猴繁殖群由187只成年繁殖动物（134只雌性和53只雄性），102只后代（75只雌性，27只雄性）和38只哺乳后代（22只雌性，16只雄性）组成。从这个繁殖群体中被消灭的病毒有：1型猿猿疱疹病毒、D型猴逆转录病毒、猴t淋巴细胞病毒和猴免疫缺陷病毒。尽管这个群体自2002年开始繁殖以来一直很成功，但在固定笼子里的那部分群体中，腹泻的发生率相当高。中心动物服务部人员认为，腹泻的发生与饲养这些动物的固定笼子有直接关系。这项修订的拨款提案的具体目的是获得资金，用现代移动笼取代所有留在特定无病原体区域的固定笼。这一翻新项目的资金将对SPF群体的整体健康产生积极影响；将提高该司畜牧业计划的效力和效率；并将为中心的研究人员提供特定的无病原体猕猴和他们成功执行资助研究计划所需的研究支持。

DESCRIPTION (provided by applicant): Currently, the Specific Pathogen Free rhesus macaque breeding colony of the Wisconsin National Primate Research Center consists of 187 adult breeding animals(134 females and 53 males), 102 offspring that will be utilized as replacement breeders as they mature (75 females, 27 males), and 38 nursing offspring (22 females, 16 males).The viruses that have been eliminated from this breeding colony are Cercopithecine herpesvirus 1, Type D Simian Retrovirus, Simian T-Lymphotropic Virus, and Simian Immunodeficiency Virus. Despite the fact that the colony has been reproductively successful since its inception in 2002, the incidence of diarrhea in the portion of the colony that is housed in stationary caging is quite high. The personnel of the Animal Services Division of the Center believe that the incidence of diarrhea is related directly to the stationary cages where these animals are housed. The specific aim of this revised grant proposal is to obtain funding to replace all of the stationary caging that remains in the Specific Pathogen Free area with contemporary mobile caging. Funding of this renovation project will have positive effects on the overall health of the SPF colony; will improve the effectiveness and efficiency of the Division's husbandry program; and will provide the Center's investigators with the specific pathogen free macaques and research support they require to successfully perform their funded research proposals.