Renovating Existing SPF Macaque Housing Space for the WNPRC

为 WNPRC 翻新现有 SPF 猕猴住房空间

• 批准号: 7433958
• 负责人: Saverio Vincent Capuano
• 金额: $ 48.02万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7433958
• 关键词: Adult; Animal Housing; Animals; Applications Grants; Area; Breeding; Cercopithecine Herpesvirus 1; Diarrhea; Discipline of Nursing; Effectiveness; Female; Funding; Health; Housing; Human Resources; Incidence; Macaca; Macaca mulatta; Primates; Research; Research Personnel; Research Proposals; Research Support; SIV; Services; Simian Retroviruses; Virus; Wisconsin; animal breeding; germ free condition; improved; male; programs

DESCRIPTION (provided by applicant): Currently, the Specific Pathogen Free rhesus macaque breeding colony of the Wisconsin National Primate Research Center consists of 187 adult breeding animals(134 females and 53 males), 102 offspring that will be utilized as replacement breeders as they mature (75 females, 27 males), and 38 nursing offspring (22 females, 16 males).The viruses that have been eliminated from this breeding colony are Cercopithecine herpesvirus 1, Type D Simian Retrovirus, Simian T-Lymphotropic Virus, and Simian Immunodeficiency Virus. Despite the fact that the colony has been reproductively successful since its inception in 2002, the incidence of diarrhea in the portion of the colony that is housed in stationary caging is quite high. The personnel of the Animal Services Division of the Center believe that the incidence of diarrhea is related directly to the stationary cages where these animals are housed. The specific aim of this revised grant proposal is to obtain funding to replace all of the stationary caging that remains in the Specific Pathogen Free area with contemporary mobile caging. Funding of this renovation project will have positive effects on the overall health of the SPF colony; will improve the effectiveness and efficiency of the Division's husbandry program; and will provide the Center's investigators with the specific pathogen free macaques and research support they require to successfully perform their funded research proposals.

说明(申请人提供)：目前，威斯康星州国家灵长类研究中心的无特定病原体恒河猴繁育群体由187只成年繁殖动物(134只雌性和53只雄性)、102只成熟后可用作替代繁殖者的后代(75只雌性，27只雄性)和38只哺乳后代(22只雌性，16只雄性)组成。已从该繁殖群体中淘汰的病毒有：脑炎疱疹病毒1型、D型猿猴逆转录病毒、猿猴T淋巴细胞病毒和猿猴免疫缺陷病毒。尽管该蜂群自2002年成立以来一直繁殖成功，但在固定笼养的蜂群中，腹泻的发生率相当高。该中心动物服务部的工作人员认为，腹泻的发生率与这些动物所在的固定笼子直接相关。这项修订的赠款提案的具体目的是获得资金，以当代移动式笼养取代留在特定病原体无病原体区域的所有固定笼养。这一改造项目的资金将对SPF种群的整体健康产生积极影响；将提高该部门畜牧业计划的效力和效率；并将为中心的研究人员提供成功执行其资助的研究提案所需的特定病原体猕猴和研究支持。