Renovating Existing SPF Macaque Housing Space for the WNPRC

描述（申请人提供）：目前，威斯康星国家灵长类动物研究中心的无特定病原体恒河猴繁殖群由187只成年繁殖动物（134只雌性和53只雄性）、102只成熟后将用作替代饲养的后代（75只雌性、27只雄性）和38只哺乳后代（22只雌性、16只雄性）组成。繁殖群体有 Cercopithecine 疱疹病毒 1、D 型猿逆转录病毒、猿 T 淋巴细胞病毒和猿免疫缺陷病毒。尽管该群落自 2002 年成立以来一直繁殖成功，但固定笼养部分群落的腹泻发生率相当高。该中心动物服务科人员认为，腹泻的发生与饲养这些动物的固定笼具有直接关系。此修订后的拨款提案的具体目标是获得资金，用现代移动笼具取代特定病原体无区域中保留的所有固定笼具。该改造项目的资助将对 SPF 群体的整体健康产生积极影响；将提高该司畜牧计划的有效性和效率；并将为该中心的研究人员提供特定的无病原体猕猴和他们成功执行资助的研究计划所需的研究支持。

DESCRIPTION (provided by applicant): Currently, the Specific Pathogen Free rhesus macaque breeding colony of the Wisconsin National Primate Research Center consists of 187 adult breeding animals(134 females and 53 males), 102 offspring that will be utilized as replacement breeders as they mature (75 females, 27 males), and 38 nursing offspring (22 females, 16 males).The viruses that have been eliminated from this breeding colony are Cercopithecine herpesvirus 1, Type D Simian Retrovirus, Simian T-Lymphotropic Virus, and Simian Immunodeficiency Virus. Despite the fact that the colony has been reproductively successful since its inception in 2002, the incidence of diarrhea in the portion of the colony that is housed in stationary caging is quite high. The personnel of the Animal Services Division of the Center believe that the incidence of diarrhea is related directly to the stationary cages where these animals are housed. The specific aim of this revised grant proposal is to obtain funding to replace all of the stationary caging that remains in the Specific Pathogen Free area with contemporary mobile caging. Funding of this renovation project will have positive effects on the overall health of the SPF colony; will improve the effectiveness and efficiency of the Division's husbandry program; and will provide the Center's investigators with the specific pathogen free macaques and research support they require to successfully perform their funded research proposals.