Renovating Existing SPF Macaque Housing Space for the WNPRC

描述（申请人提供）：目前，威斯康星州国家灵长类动物研究中心的无特定病原体恒河猴繁殖群由187只成年繁殖动物组成（134只雌性和53只雄性），102只后代将在成熟时用作替代育种者（75只雌性，27只雄性）和38只哺乳后代（22只雌性，16只雄性）。已从该繁殖群中消除的病毒是猕猴疱疹病毒1型、D型猿猴逆转录病毒、猿猴T淋巴细胞嗜性病毒和猿猴免疫缺陷病毒。尽管事实上殖民地自2002年建立以来一直繁殖成功，但在殖民地的固定笼中饲养的部分中腹泻的发生率相当高。中心动物服务部的工作人员认为，腹泻的发生与饲养这些动物的固定笼有直接关系。这项修订后的拨款提案的具体目的是获得资金，用当代移动的笼子取代所有留在无特定病原体区的固定笼子。该改造项目的资金将对SPF群体的整体健康产生积极影响;将提高该部门饲养计划的有效性和效率;并将为该中心的研究人员提供特定病原体的无猕猴和研究支持，他们需要成功执行他们资助的研究提案。

DESCRIPTION (provided by applicant): Currently, the Specific Pathogen Free rhesus macaque breeding colony of the Wisconsin National Primate Research Center consists of 187 adult breeding animals(134 females and 53 males), 102 offspring that will be utilized as replacement breeders as they mature (75 females, 27 males), and 38 nursing offspring (22 females, 16 males).The viruses that have been eliminated from this breeding colony are Cercopithecine herpesvirus 1, Type D Simian Retrovirus, Simian T-Lymphotropic Virus, and Simian Immunodeficiency Virus. Despite the fact that the colony has been reproductively successful since its inception in 2002, the incidence of diarrhea in the portion of the colony that is housed in stationary caging is quite high. The personnel of the Animal Services Division of the Center believe that the incidence of diarrhea is related directly to the stationary cages where these animals are housed. The specific aim of this revised grant proposal is to obtain funding to replace all of the stationary caging that remains in the Specific Pathogen Free area with contemporary mobile caging. Funding of this renovation project will have positive effects on the overall health of the SPF colony; will improve the effectiveness and efficiency of the Division's husbandry program; and will provide the Center's investigators with the specific pathogen free macaques and research support they require to successfully perform their funded research proposals.