Strengthening Indian NCD clinical research and training capacity

描述（由申请人提供）：印度的非传染性疾病负担正以惊人的速度增加，例如，现在包括5000万糖尿病患者。研究和预防规划既能提高认识，又能提供有效和高效的行动战略，从而减轻这一繁重的负担。该提案通过UAB与位于金奈的马德拉斯糖尿病研究基金会（MDRF）合作制定的ICOHRTA下的机构和个人能力建设和培训计划来解决这一负担。发展起来的非常成功的培训模式从学位培训扩展到机构能力建设，并在职业阶段和道路上广泛提高个人研究能力，主要侧重于印度境内的活动。它在印度举办了一次国际培训研讨会，广泛讨论非传染性疾病问题，旨在为来自一系列医学院和卫生部门研究所和机构的代表提供认识和技能，并提高它们的能力。该研讨会每年包括100多名代表和20多名教员，其中包括一个美国团队和一些备受尊敬的印度科学家和教育家。此外，还建议继续举办每年10个具体研究项目的密集会议，每年在2个以上的机构举办一系列旨在建立研究所能力和加强论文项目的内部讲习班，以及一系列研讨会，其中一些在建议的每月两次的视频会议期间举行，另一些在访问机构期间举行。另一个提议的组成部分是继续在美国进行为期4年的短期培训，进行预先确定的高度集中的培训。事实证明，这一整体战略在培养博士方面成效显著，自2002年以来完成了18项研究，目前有24项正在进行中，这些人都留在了印度，除了在美国的博士后。重要的新举措将扩大正在进行的计划的广度和深度，包括创建社区医学教师论坛；重点是制定非传染性疾病共同定义和数据收集程序；培训培训师计划，旨在通过网页随时提供现有程序和方法以及上述论坛和共同方法活动的结果；每年至少增加一个新的合作机构的程序；在MDRF开设新课程并继续和扩大基因组学培训计划的过程。这些拟议的活动将继续影响参与机构和印度以外的非传染性疾病研究的范围和性质，超出它们已经产生的相当大的影响。学员现在在印度卫生部门担任重要职务。此外，MDRF和受训者在合作期间制定了一个最值得称赞的科学项目和发表记录。活动的方针和性质将由现有的内部咨询委员会和即将设立的培训咨询委员会指导。

DESCRIPTION (provided by applicant): India's NCD burden is increasing at an alarming rate, now including, eg, >50 million diabetics. This demanding burden can be lessened by research and prevention programs both create awareness and provide effective and efficient strategies for action. This proposal targets this burden with an institution and individual capacity building and training program developed under ICOHRTA by a collaboration between UAB and the Madras Diabetes Research Foundation (MDRF) in Chennai. The highly successful training model that evolved goes beyond degree training to institutional capacity building and enhancing individual research capability broadly across career stages and paths with a major focus on activities within India. It addresses NCD broadly with an International Training Seminar held in India and designed to provide awareness and skills for delegates from, and enhancing the capacity of, an array of medical colleges and health sector institutes and agencies. The seminar includes annually >100 delegates and >20 faculty, a mixture of a US team and a selection of highly respected Indian scientists and educators. Also proposed are continuing the Intensive Sessions with a focus on 10 specific research projects per year, a series of in-house workshops at 2+ institutions per year designed to build institute capacity and enhance dissertation projects and a seminar series, some during the proposed twice-monthly video conferences and some during visits to the institutions. Another proposed component is to continue the short-term training in the US, for 4/year for pre-determined highly focused training. This overall strategy has proven highly productive in producing PhDs, with 18 completed since 2002 and 24 currently underway with the added benefit that all these persons remain in India except a post-doc in the US. Important new initiatives will expand the breadth and depth of the ongoing program and include creating a Community Medicine Faculty Forum; a focus on Developing Common NCD Definitions and Data Collection Procedures; a Train the Trainers Program, designed to make existing procedures and methods plus those a result of the Forum and common methods activities above readily available via a webpage; a process for adding new collaborating institutions, at least one per year; a process for creating new courses at MDRF and continuing and expanding a Genomics Training Program. These proposed activities will continue to influence the extent and nature of NCD research at the participating institutions and beyond to India, beyond their already considerable impact. Trainees now hold important positions in the health sector in India. Further MDRF and the trainees have developed a most laudable scientific project and publication record during the collaboration. The course and the nature of the activities will be guided by the existing Internal Advisory Committee and the Training Advisory Committee to be created. PUBLIC HEALTH RELEVANCE: Cardiovascular disease and diabetes, eg, have become major health problems in India and other developing countries, with the prevalence of diabetes having gone from 2.1% in 1970 to more than 15% now so that there are some 30-50 million diabetics in the country. Non communicable disease relevant clinical research capacity building and training are thus a critical component of efforts to stem this tide.