UIC Center for Population Health and Health Disparities

描述（由申请人提供）：本提案是为了更新ulc人口健康和健康差异中心（P50 CA10674）。该中心是由国家癌症研究所全部或部分资助的五个中心之一，是美国国立卫生研究院最初倡议的一部分。这是一个多重主要研究者的申请。该中心的主题是：了解我们之前的研究如何确定与种族/民族相关的乳腺癌诊断阶段差异的根本原因，从而导致基于该研究的干预措施？根据我们迄今为止的工作，建议更新中心的当前目标是解决三个问题，这些问题已成为理解白人妇女和有色人种妇女在乳腺癌诊断阶段差异的核心问题。它们是：I)确定在安全网医院中如何解决早期发现、诊断和治疗方面的明显差异？2a)确定社区卫生诊所如何更有效地识别和监测有患侵袭性乳腺癌风险的患者。2b)确定如何让高风险患者参与量身定制的筛查和监测计划。3)确定生物因素，特别是DNA甲基化，如何在有色人种女性中不成比例地促进侵袭性乳腺癌？。有三个项目：。1)医疗服务不足地区的患者导航。（E. Calhoun， PI） 2)乳腺癌筛查干预提高服务不足的少数民族妇女对癌症控制指南的依从性（K. Hoskins， PI）；DNA甲基化和不同种族/民族的癌症侵袭性差异（G. Rauscher， PI）和四个核心：管理(R. Warnecke (Contact) & E. Calhoun (Co- Core leaders)；政策和传播（C. Ferrans， CL）；数据管理与评估（T. Johnson, (CL)）和培训与职业发展（F Davis， CL）我们持续的、长期的愿景是通过多层次和多学科的人口健康战略来测试和建立干预措施，解决人口健康差异的决定因素。为了实现这一目标，我们将：1)开展研究，影响管理乳房x光检查和乳腺癌管理的政策，确保平等获得标准的乳腺癌护理，无论在哪里提供，无论谁提出要求。2)使贫穷和服务不足的妇女认识到需要以确保最佳结果的方式获得护理。3)培养跨学科视角的健康差异研究青年学者。

DESCRIPTION (provided by applicant): This proposal is for renewal of the UlC-Center for Population Health and Health Disparities (P50 CA10674). This Center is one of five that were funded in whole or in part by the National Cancer Institute as part of the initial NIH initiative. It is a Multiple Principal Investigator application. The center theme is: Understanding how our previous research identifying fundamental causes of disparities in stage at breast cancer diagnosis related to race/ethnicity can lead to interventions grounded in that research? The current aims of the proposed renewal of the Center are to address three questions that have emerged as central issues in understanding the disparity in stage at breast cancer diagnosis between White women and women of color based on our work to date. These are: I) To define how apparent disparities in early detection, diagnosis and treatment can be addressed in safety-net hospitals? 2a) Determine how community health clinics can more effectively identify and monitor patients at risk for aggressive breast cancer. 2b) Determine how patients at elevated risk can be engaged to participate in a tailored screening and monitoring program. 3) To determine how biological factors, specifically DNA methylation, promote aggressive breast cancer disproportionately among women of color? . There are three projects: .1) Patient Navigation in Medically Underserved Areas. (E. Calhoun, PI) 2) A Breast Cancer Screening Intervention to Improve Adherence to Cancer Control Guidelines in Underserved Minority Women (K. Hoskins, PI); DNA Methylation and Differential Cancer Aggressiveness by Race/Ethnicity (G. Rauscher, PI) and four cores: Administration (R. Warnecke (Contact) & E. Calhoun (Co- Core leaders); Policy and Dissemination (C. Ferrans, CL); Data Management and Evaluation (T. Johnson, (CL) and Training and Career Development (F Davis, CL ) Our continuing, long range vision is to test and establish interventions that address determinants of population health disparities by approaching them with a multilevel and multidisciplinary population health strategy. To accomplish this we will: 1) conduct research that impacts the policies that govern access to mammography and management of breast cancer and ensures equal access to the standard of breast cancer care regardless of where it is delivered and who requests it. 2) Enable women who are poor and underserved to recognize the need to access the care in ways that ensure the best outcomes. 3) To train young scholars in health disparities research incorporating a transdisciplinary research perspective.