Collaborative Observational Study of Myopia in Comet Children

描述(由申请人提供)：根据COSMICC2协议，宾夕法尼亚视光学院临床中心继续每年检查93名目前在宾夕法尼亚视光学院临床中心登记的COSMICC参与者(自1997-98年登记以来，只有15名受试者失去随访)，为期5年(总随访14年)。从这个中心收集的数据将被用来解决主席申请中更详细描述的具体目标，并在这里简要总结：1)使用数学函数(Gompertz函数和其他函数)来模拟58%的COSMICC进行性近视受试者的近视进展，并基于先前确定的风险因素(年龄、种族、父母近视)开发预测模型和测试假说；2)在这个特征良好的近视队列中测试与近视进展和稳定以及眼轴延长的环境风险因素有关的4个假说；3)对COSMICC受试者近视相关眼压、CCT和黄斑厚度变化的危险因素进行三个假设检验。近视的高患病率(占美国成年人口的25%)及其作为公共卫生问题的突出(可能导致视力丧失和失明的危险因素)强调了增加对进展和最终稳定的机制的了解的重要性，以便将来近视可能被限制在低水平。更好地了解近视进展和稳定的预测因素也将有助于指导干预措施的选择和时机，并针对那些可能从治疗中受益最大的群体。这份申请证明了宾夕法尼亚验光学院遵循COSMICC2程序手册并将患者保留五年的能力。文件还规定，宾夕法尼亚验光学院拥有根据COSMICC2程序手册进行研究的人员、设备和设施。

DESCRIPTION (provided by applicant): This proposal is for the Pennsylvania College of Optometry Clinical Center to continue to annually examine the 93 currently enrolled COSMICC participants (only 15 subjects have been lost to follow-up since enrolled in 1997-98) at the Pennsylvania College of Optometry center for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment. This application documents the Pennsylvania College of Optometry's ability to follow the COSMICC2 Manual of Procedures and to retain patients for five years. Documentation is also provided that the Pennsylvania College of Optometry has the personnel, equipment, and facilities to conduct the study in accordance with the COSMICC2 Manual of Procedures.