Peripheral Blood Collection and Chracterization of Adult Stem Cells.

摘要：成人红细胞起源于人外周血中的造血干细胞，对促红细胞生成素有反应。这一过程被称为红细胞生成。在许多红系疾病中，包括血红蛋白病、贫血和红白血病，红细胞生成过程是异常的或被潜在的病理损害。为了更好地了解这些疾病的分子机制，人们利用从人类外周血中采集的造血干细胞建立了体外红细胞生成模型系统。在这项研究中，细胞从外周血中采集，用于体外红细胞生成的检测。此外，与输血医学部的合作旨在改进造血干细胞的收集方法，并正在为红系疾病患者开发专门的方法。

Summary: Adult human erythroblasts arise from hematopoietic stem cells in the peripheral blood of humans in response to erythropoietin. This process is called erythropoiesis. In many erythroid diseases including hemoglobinopathies, anemia and erythroleukemia, the process of erythropoiesis is abnormal or damaged by the underlying pathology. In order to better understand the molecular mechanisms responsible for these diseases, ex vivo model systems of erythropoiesis were developed using hematopoietic stem cells collected from the peripheral blood of humans. In this study, cells are harvested from peripheral blood and used for ex-vivo assays of erythropoiesis. In addition, collaborative efforts with the department of transfusion medicine are aimed toward improved methods for the collection of hematopoietic stem cells, and specialized methods are being developed for patients with erythroid diseases.