2017 RNA Editing Gordon Research Conference and Gordon Research Seminar

项目摘要/摘要 RNA和DNA在所有生物体中都经历了各种各样的程序化化学修饰，而这些 变化对许多生物过程都是必不可少的，包括新陈代谢、基因调节、大脑功能、 豁免权和进化。这些过程中的缺陷表现为疾病状态，包括癌症、神经疾病 疾病、免疫缺陷综合症和传染病。虽然不同的分子机器是 负责在任何给定的有机体中生成大量和多样化的修改指令集， 研究这些过程的研究人员经常遇到类似的理论和技术挑战。 因此，迫切需要在这一广泛领域的前沿促进研究人员之间的会议，以便 克服这些障碍并促进对潜在生物学和结果的更深层次的理解 疾病过程。每两年举行一次的RNA编辑戈登研究会议(GRC)是唯一一次国际 专门讨论这项任务的会议。2017年会议有三大目标。Aim 1将展示最新的 研究影响人类健康的编辑和修改机制和技术。这一目标将是 通过9次演讲完成，包括一位诺贝尔奖得主的主旨演讲 通过4个海报会议和75个海报演示。该计划的组织是为了最大限度地进行讨论， 学习、指导和建立网络的机会。目标2将为新的和有影响力的项目创造机会 编辑和修改领域的老牌调查人员与新的 调查人员和/或对该领域不熟悉的老牌调查人员。这一目标将通过以下方式实现 为正式和非正式讨论提供机会。所有会谈之后都将进行正式讨论，而非正式讨论 讨论将在休息、用餐、开放的下午、海报会议和晚上的社交活动中进行。目标 将为所有学生、博士后、 以及代表不足的受训者，他们注定要成为下一代科学的领导者。这 将通过举办一天半的戈登研究研讨会(GRS)为学生和 GRC之前的博士后实习生。GRS将有12个口头演示和25个海报演示， 以及一位改装领域先驱的职业发展主题演讲。GRS将提供一个 为学生和博士后实习生提供的专门论坛，用于介绍和讨论研究以及与同行建立网络 在参加GRC之前。这一重要活动帮助学员变得放松并为 在GRC期间，与资深导师互动并向他们学习。此外，GRC还将以教育性的 《机遇》杂志名为《力量一小时》，讲述了女性在科学领域面临的独特挑战。这 新奇活动将由RNA编辑领域的一位领导者和一位科学领域的女性倡导者主办。总的来说， 这次两年一度的会议对于编辑和修改领域的持续增长和进步至关重要， 其他领域的异花授粉，以及下一代科学家的培养。

PROJECT SUMMARY / ABSTRACT RNA and DNA undergo a wide variety of programmed chemical modifications in all organisms, and these changes are essential for many biological processes including metabolism, gene regulation, brain function, immunity, and evolution. Defects in these processes manifest as disease states including cancer, neurological diseases, immunodeficiency syndromes, and infectious diseases. While different molecular machines are responsible for generating the large and diverse repertoire of modifications in any given organism, the researchers investigating these processes routinely encounter similar theoretical and technical challenges. Thus, there is a strong need to foster a meeting among researchers at the forefront of this broad area in order to overcome these hurdles and promote a deeper understanding of the underlying biology and resulting disease processes. The biennial RNA Editing Gordon Research Conference (GRC) is the only international meeting devoted to this mission. The 2017 meeting has three major aims. Aim 1 will be showcasing the latest research on editing and modification mechanisms and technologies that impact human health. This aim will be accomplished through 9 oral sessions with >60 talks including a keynote lecture by a Nobel Laureate, as well as through 4 poster sessions with >75 poster presentations. The program is organized to maximize discussion, learning, mentoring, and networking opportunities. Aim 2 will be creating opportunities for new and impactful collaborations to develop between established investigators in editing and modification field and new investigators and/or established investigators who are new to this area. This aim will be accomplished by providing opportunities for formal and informal discussions. Formal discussions will follow all talks, and informal discussions will occur during breaks, meals, open afternoons, poster sessions, and evening social periods. Aim 3 will be providing presentation, mentoring, and career development opportunities for all student, post-doctoral, and under-represented trainees, who are destined to become the leaders of the next scientific generation. This will be accomplished by holding a one and half day Gordon Research Seminar (GRS) for student and postdoctoral trainees prior to the GRC. The GRS will have 12 oral presentations and >25 poster presentations, as well as a career development keynote by a pioneer in the modification field. The GRS will provide a dedicated forum for student and postdoctoral trainees to present and discuss research and network with peers before participating in the GRC. This important event helps trainees to become relaxed and prepared to engage and learn from senior mentors during the GRC. Additionally, the GRC will also feature an educational opportunity called the Power Hour, which addresses the unique challenges faced by women in science. This novel event will be hosted by a leader in the RNA Editing field and an advocate for women in science. Overall, this biennial meeting is vital for the continued growth and advancement of the editing and modification fields, the cross-pollination of other fields, and the training of the next generation of scientists.