Transgenerational work exposures, EDCs and male fertility

项目摘要 男性不育和生育力低下约占10-15%的总患病率的一半， 怀上孩子在过去的二十年里，大量的证据表明， 成年男性生殖功能障碍男性生殖功能障碍可以在- 一代人，与父母的工作有助于男性生育力低下的下一代，并增加 成年男性在子宫内或通过父母职业暴露于第二次伤害的脆弱性。我们将使用 关于男性生殖参数、职业数据和相关协变量的数据， 未来家庭研究（SFF）探讨职业对男性抑郁症的作用 生育指数，包括精液质量参数、男性激素水平和睾丸大小 测量.职业暴露指数将包括报告的职业、具体工作暴露 一个描述内分泌干扰化学品暴露的工作暴露矩阵。 此外，使用一套独特的关于职业暴露的母亲问卷数据，我们将 通过建立直接和间接模型，评估代际对男性生殖指数的影响 父母和男性伴侣职业暴露对男性生育能力的影响。这将 评估男性易受第二次侮辱的脆弱性（因父母职业接触而产生）， 生殖能力这项建议是第一批审查职业照射作用的建议之一 男性受试者的父母生育能力下降或易受职业伤害 在下一代的曝光。该数据集的丰富性，结合 男性生育力参数与父母职业数据，是一个机会，以测试一个新的假设 男性生殖缺陷的代际传递这项拟议研究的结果将奠定 为努力减少育龄男子和 几代人的女人。该提案涉及诺拉癌症跨部门计划， 生殖和心血管疾病，与其他疾病预防控制中心的合作伙伴，旨在更好地识别和 控制生殖毒物暴露，并与医疗保健工作者的健康有关， 制造业和建筑诺拉部门。正如NIOSH计划组合所指出的那样， 职业暴露对男性和女性不育症的影响仍然未知;这项工作将 为男性和代际工作场所的研究议程做出重大贡献 暴露和生育能力。这项工作支持NIOSH的r2 p倡议，提供详细信息， 工作场所有害的生殖接触及其缓解，以及加强保护 这些工人可能因先前的父母接触而面临更大的风险。

Project Summary Male infertility and subfertility accounts for roughly half of the 10-15% prevalence of overall failure to conceive a child. An accumulated body of evidence across the past two decades suggests fetal origins of adult male reproductive dysfunction. Male reproductive dysfunction could proceed inter- generationally, with parental work contributing to male subfertility in the next generation, and increased vulnerability to second insult in the adult male exposed in utero or via parental occupation. We will use data on male reproductive parameters, occupational data, and relevant covariates collected by the Study for Future Families (SFF) to examine the role of occupational contributions to depression of male fertility indices including semen quality parameters, male hormonal levels, and testicular size measurements. Occupational exposure indices will include reported occupation, specific job exposures reported in the SFF, and a job-exposure matrix describing exposure to endocrine-disrupting chemicals. Additionally, using a unique set of maternal questionnaire data on occupational exposures, we will assess intergenerational influences on men's reproductive indices by modeling direct and mediated effects of both parental and male-partner occupational exposures on male fertility profiles. This will assess male vulnerability (arising from parental occupational exposure) to a second insult to reproductive capacity. This proposal is one of the first to examine the role of occupational exposures sustained by parents of male subjects in reduced fertility or susceptibility to insult from occupational exposures in the subsequent generation. The richness of this dataset, combined with the linkage of male fertility parameters with parental occupational data, is an opportunity to test of a novel hypothesis on intergenerational transmission of male subfecudity. The findings of this proposed study will lay the groundwork for efforts to reduce potentially hazardous occupational exposures in both fertile men and women across generations. This proposal addresses the NORA cross-sector program in Cancer, Reproductive and Cardiovascular Diseases which, with other CDC partners, aims to better identify and control reproductive toxicant exposures, and is relevant to the health of workers in the Healthcare, Manufacturing, and Construction NORA sectors. As the NIOSH Program Portfolio notes, the overall contribution of occupational exposures to male and female infertility remains unknown; this effort will make a significant contribution toward a research agenda on male and intergenerational workplace exposures and fertility. The work supports NIOSH r2p initiatives in providing detailed information on adverse reproductive exposures in the workplace, and their mitigation, as well as increasing protection of workers who may be at greater risk from prior parental exposures.