Neurogenic diarrhoea: lessons from cholera toxin and related bacterial exotoxins

许多导致腹泻的细菌通过肠道自身的神经系统大量增加水和盐进入肠道管腔的运输。在这个项目中，我们将研究导致肠道神经系统过度兴奋的机制，以验证这是由于控制水运输的正常途径中最终神经细胞的特性发生变化所致。这将确定药物治疗腹泻的新地点。

Many bacteria that cause diarrhoea act via the gut’s own nervous system to massively increase the transport of water and salt into the lumen of the intestine. In this project we will investigate mechanisms that lead to this over-excitation of the gut’s nervous system to test the idea that this is due to a change in the properties of the final nerve cells in the normal pathway that controls water transport. This will identify novel sites for drug treatments of diarrhoea.