Neuromodulation of triggering of transient lower oesophageal sphincter relaxation and gastro-oesophageal reflux

胃内容物回流到食道是一种非常常见的情况。如果不治疗反流，可能会出现更严重的问题。在反流病患者中，食道和胃之间的连接处的解剖结构发生改变。这项研究计划将进行新的研究，以探索这种改变如何加剧饭后的触发反流，并可能为这一常见问题确定药物治疗的新靶点。

Reflux of stomach contents into the gullet is a very common condition. If reflux is not treated, more severe problems may manifest. In patients with reflux disease the anatomy of the junction between the gullet and the stomach is altered. This research program will undertake novel studies to explore how this alteration exacerbates the triggering reflux after a meal and potentially identify new targets for pharmacological therapy for this common problem.