Topic 394 - A versatile radiation-triggered phosphor platform for localized anti-cancer therapy

本计画的目标是制备一种新型的纳米闪烁体-光敏剂复合物，以应用于X光激发光动力疗法。 在本文中，低剂量的X射线（<1戈伊）用于激发电离纳米颗粒，其将电离辐射下转换为UV-可见光。 装载到纳米闪烁体复合物上的光敏剂吸收这种紫外-可见光发射，并在肿瘤微环境中产生细胞毒性活性氧（ROS）。 长期目标是通过独特的X射线激发光动力治疗平台（*XPDT）克服光激活光敏剂的深度限制，其中低剂量的局灶性或全身性辐射可以分别根除局部或转移性胰腺癌。 技术创新包括新型纳米复合物的制造、使用新型闪烁检测平台进行纳米复合物之间的比较、体外和体内测试以及新型激发X射线源的使用。

The goal of this project is to fabricate a novel nanoscintillator-photosensitizer complex for X-ray excited photodynamic therapy (XPDT). Herein, a low dose of X-rays (<1 Gy) is used to excite scintillating nanoparticles, which downconvert ionizing radiation to UV-vis light. Photosensitizers loaded onto the nanoscintillator complex absorb this UV-vis emission and generate cytotoxic reactive oxygen species (ROS) in the tumor microenvironment. The long-term objective is to overcome the depth limitation of light-activated photosensitizers through an unique X-ray excited photodynamic therapy platform (*XPDT), wherein a low dose of focal or generalized radiation can eradicate localized or metastatic pancreatic adenocarcinomas, respectively. Technological innovations include the fabrication of a novel nanocomplex, comparison between nanocomplexes using a novel scintillation detection platform, in vitro and in vivo testing, and the use of a novel excitation X-ray source.