Immuno-Oncology Translation Network (IOTN): Cellular Immunotherapy Data Resource (CIDR)

项目摘要/摘要 国际血液和骨髓移植研究中心(CIBMTR)作为一项数据有着悠久的历史 为造血细胞移植和细胞治疗提供资源。细胞的发展 免疫治疗数据资源(CIDR)将利用CIBMTR基础设施进行数据库开发， 数据共享，与参与中心联网，以及细胞疗法的临床研究 癌症。此外，还可以采用创新的方法来优化从收件人那里获取的长期跟踪数据 将探索转基因细胞，例如利用患者报告的电子结果工具。 为研究提供高质量的数据是CIDR的主要目标之一。拟议中的项目 使用各种方法来促进资源的使用，包括访问准备好的数据集、报告 和出版物，快速响应定制数据集的请求，以及评估和确定优先顺序的系统 对统计支持的请求。后者将由在生存方面拥有深厚专业知识的统计学家提供 分析。最后，与多个利益攸关方合作，包括专业协会、认证机构、 行业、治疗中心和代表肿瘤学、血液学、细胞学等多个领域的研究人员 加工和免疫学将优化CIDR资源的利用，促进快速崛起的 细胞免疫治疗领域。

PROJECT SUMMARY/ABSTRACT The Center for International Blood and Marrow Transplant Research (CIBMTR) has a long history as a data resource for hematopoietic cell transplantation and cellular therapy. Development of the Cellular Immunotherapy Data Resource (CIDR) will leverage the CIBMTR infrastructure for database development, data sharing, networking with participating centers, and clinical research in cellular therapy for the treatment of cancer. Additionally, innovative approaches to optimize capture of long-term follow-up data from recipients of genetically modified cells will be explored, such as utilization of electronic patient-reported outcome tools. Providing access to high quality data for research is among the main goals of the CIDR. The proposed project employs a variety of methods to promote use of the resource, including access to prepared datasets, reports and publications, rapid response to requests for custom datasets, and a system to evaluate and prioritize requests for statistical support. The latter will be provided by statisticians with deep expertise in survival analysis. Finally, collaboration with multiple stakeholders, including professional societies, accreditation bodies, industry, treating centers, and investigators representing multiple areas of oncology, hematology, cell processing, and immunology will optimize utilization of the CIDR resource and advance the rapidly emerging field of cellular immunotherapy.