Core 2: Biostatistics and Bioinformatics Core

项目总结/摘要 生物统计学和生物信息学核心（BBC）将促进前列腺癌的转化研究， 为加州大学洛杉矶分校的研究人员和他们的同事提供最先进的生物统计学，生物信息学和临床 审判支持。英国广播公司提供了一个集中的网络的生物统计学和生物信息学支持前列腺 加州大学洛杉矶分校的癌症研究人员及其合作者。核心的总体目标是提供统计和 为SPORE的基础和临床研究人员提供生物信息学支持。统计咨询将由 博士大卫Elashoff和李刚博士的支持下，将包括咨询功率分析和 用于临床前和临床研究规划的实验设计。核心将合作开发 统计分析计划，并协助执行这些计划。生物信息学部分将由 由托马斯格雷伯博士和保罗布特罗斯博士支持。核心为所有人提供分析服务 基因组学研究，包括RNA/整个外显子组/T细胞受体测序和蛋白质组学分析， 孢子。对于这些数据类型，核心将协助数据预处理，管道开发和云计算 计算、质量控制评估、标准和定制集成和网络分析。核心 将协助报告研究成果的手稿。最后，生物统计学和生物信息学核心 每年为所有SPORE调查人员提供教育研讨会和课程。

PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core (BBC), will facilitate translational research in prostate cancer, by providing UCLA investigators and their colleagues with state of the art biostatistical, bioinformatics and clinical trials support. The BBC provides a centralized network of biostatistics and bioinformatics support for prostate cancer researchers at UCLA and their collaborators. The overall goal of the Core is to provide statistical and bioinformatic support to basic and clinical investigators in the SPORE. The statistical consulting will be led by Dr. David Elashoff and supported by Dr. Gang Li and will include consultation on power analyses and experimental design for planning of preclinical and clinical studies. The core will collaborate on the development of statistical analysis plans and assist with carrying out those plans. The Bioinformatics component will be led by Dr. Thomas Graeber and supported by Dr. Paul Boutros. The Core provides analytical services for all genomics research, including RNA/whole exome/T-cell receptor sequencing and proteomic analysis within the SPORE. For these data types the core will assist with data preprocessing, pipeline development and cloud computing, quality control evaluation, and both standard and custom integrative and network analysis. The core will assist with the reporting of research findings in manuscripts. Finally, the Biostatistics and Bioinformatics Core provides yearly educational seminars and courses to all SPORE investigators.