Core B: Small Animal Radiation Core

项目总结 小动物辐射核心(SARC)的总体目标是为 植入肿瘤的外壳和光子和质子辐射(包括图像引导辐射) 变成同基因小鼠以及自发的、自体的肿瘤。此外，它还将提供 成功完成研究所需的准确剂量测定和质量控制 在项目2和3中提出。该核心的一个关键特征是集中化和 旨在最大限度减少免疫方面动物间差异的服务标准化 系统调节与肿瘤对辐射的反应。我们设计了一个简化的流程，以 动物从订购(C57/BL6)或从繁殖中获得(KPC胰腺)的移动 肿瘤模型)，直到动物被安乐死和 肿瘤和组织被收获。在这个核心的中心是一个专门的动物收容所 设施和一个全新的翻新的动物治疗室，将容纳和已经 提供并建立小动物辐射研究平台(SARRP)仪器，来自 X-Strahl，Inc.以及斯米洛翻译中心提供的专用质子束 研究(SCTR)。这一核心的三个主要目标是：目标1：建立一个专门的 带有受控环境参数的住房套间。目标2：同时提供光子和 小动物质子适形照射小鼠肿瘤的研究 无线电平台(SARRP)和可用的质子束，从而避免正常辐射 尽可能多地使用纸巾。目标3：发展精确的剂量测定和质量控制分析 系统，以确保规定的剂量被送到目标。两位联席董事，Dr。 Koumenis和Solberg带来了小动物辐射方面的大量专业知识以及 管理宾夕法尼亚大学和以前的机构的辐射设施。成功实施 这些服务将为项目负责人提供无缝和统一的治疗模式和 有可能成为世界范围内其他类似研究工作的示范设施。

PROJECT SUMMARY The overall goal of the Small Animal Radiation Core (SARC) is to provide “turn-key” animal housing and photon and proton radiation (including image-guided radiation) to tumors implanted into syngeneic mice as well as spontaneous, autocthonous tumors. Moreover, it will furnish accurate dosimetry and quality control necessary for successful completion of the studies proposed in Projects 2 and 3. A key feature of this Core is the centralization and standardization of services intended to minimize inter-animal variability in terms of immune system regulation and tumor response to radiation. We have devised a streamlined process for movement of animals from ordering (C57/Bl6) or procuring them from breeding (KPC pancreatic tumor model) to tumor radiation and back to housing until the animals are euthanized and tumors and tissues are harvested. At the center of this Core is a dedicated animal holding facility and a brand new renovated animal treatment room which will house and already available and established Small Animal Radiation Research Platform (SARRP) instrument from X-Strahl, Inc as well as dedicated proton Beam available in the Smilow Center for Translational Research (SCTR). The three main aims of this core are: Aim 1: To establish a dedicated housing suite with controlled environmental parameters. Aim 2: To deliver both Photon and Proton-based irradiation to mouse tumors in a conformal manner using the Small Animal Radiaiton Platform (SARRP) and available Proton Beam thereby avoiding radiation of normal tissues as much as possible. Aim 3: To develop precise dosimetry and quality-control analysis systems to ensure the prescribed dose was delivered to the target. The two co-Directors, Drs. Koumenis and Solberg, bring considerable expertise in small animal radiation as well as managing radiation facilities both at Penn and prior Institutions. Successful implementation of these services will provide the Project Leaders seamless and uniform treatment modalities and has the potential to serve as a model facility for other similar research efforts world-wide.