Clinical Research in ALS & Related Disorders for Therapeutic Development (CReATe) - Career Enhancement Core

项目总结/摘要 初级教师（包括MD和博士）的职业提升一直是CReATe联盟的优先事项 通过其第一个周期的资金，与我们的CREATe学者正在成功地确保校外资金， 在高影响力的期刊上发表成果，确保初级教师职位，并成为该领域的领导者。 更广泛地在该领域内。CReATe职业提升核心的目标是 识别和选择希望从事罕见疾病研究的最有前途的候选人 专注于ALS和相关疾病;为这些CReATe学者提供支持，机会和 有利他们成功职业发展的环境;以及协同促进职业发展 CReATe联盟与罕见疾病临床研究网络（RDCRN）的活动， 神经学/神经科学社区更广泛。为此，我们将为每一位CReAT学者提供 提供一系列培训、指导、资源和合作机会，并使每位学者能够 根据自己的独特需求，量身定制职业提升计划。可用的机会包括： (1)教学法，通过国家CTSA计划，NINDS卓越网络利用现有计划 临床试验，NINDS临床试验方法课程，RDCRN R25罕见疾病证书计划， 和RDCRN罕见疾病研究临床会议;（2）本地和远程导师制;（3） 建立联系，包括有机会与其他机构的调查员轮流访问; ⑷旅行 津贴，以便能够参加国家和国际会议并在会上介绍成果;（5）获得 到CReATe资源（数据存储库、生物存储库、St. Jude Cloud等）以及我们的合作伙伴 例如靶向ALS（例如，人体组织核心）;以及（6）参与患者倡导团体和其他 战略合作伙伴计划，如ALS宣传日、科学审查委员会和患者支持 组我们的培训计划的意义和影响最终将由职业轨迹来判断 和成就的医生研究人员和翻译科学家我们训练。

Project Summary / Abstract Career enhancement of junior faculty (both MD and PhD) has been a priority for the CReATe Consortium through its first cycle of funding, with our CReATe Scholars being successful in securing extramural funding, publishing results in high impact journals, securing junior faculty positions, and emerging as leaders within the Consortium and more broadly within the field. The goals of the CReATe Career Enhancement Core are to identify and select the most promising candidates who wish to pursue a career in rare disease research focused on ALS and related disorders; provide these CReATe Scholars with support, opportunities and an environment that is conducive to their successful career growth; and synergize the career enhancement activities of the CReATe Consortium with those of the Rare Diseases Clinical Research Network (RDCRN) and the neurological/neuroscience community more broadly. To these ends, we will provide each CReATe Scholar with an array of training, mentorship, resource and partnership opportunities, and empower each Scholar to tailor their career enhancement program to match their own unique needs. Available opportunities will include: (1) didactics, leveraging existing programs through the National CTSA program, NINDS Network of Excellence in Clinical Trials, NINDS Clinical Trials Methods Course, the RDCRN R25 Rare Diseases Certificate Program, and RDCRN Clinical Conference on Research in Rare Diseases; (2) mentorship, both local and remote; (3) networking, including opportunities for visiting rotations with investigators at other institutions; (4) travel stipends, to enable participation and presentation of results at national and international meetings; (5) access to CReATe resources (data repository, biorepository, St. Jude Cloud, etc.) as well as those of our partners such as Target ALS (e.g. human tissue core); and (6) participation in patient advocacy group and other strategic partner initiatives such as ALS Advocacy Day, scientific review committees, and patient support groups. The significance and impact of our training program will ultimately be judged by the career trajectories and accomplishments of the physician investigators and translational scientists whom we train.