Dual Role for Innate Lymphoid Cells in Pathogenesis of Brucellosis

项目摘要/摘要： 布鲁氏菌感染会引起无数的症状，因为布鲁氏菌几乎可以感染 任何器官或器官系统。天然淋巴样细胞在粘膜组织中含量丰富， 作为布鲁氏菌感染的入口，我们发现天然淋巴样细胞调节 布鲁氏菌感染的炎症和控制。在这个提案中，我们将研究相互作用 在固有淋巴样细胞和炎性小体之间，以确定固有淋巴样细胞如何从 不同的组织调节布鲁氏菌引起的炎症。我们还将确定相关的 不同先天淋巴细胞亚群对控制炎症和布鲁氏菌的作用 感染。总而言之，我们的研究结果将加深我们对布鲁氏菌是如何产生的了解 能够利用粘膜部位作为感染的门户，并在不同的宿主内引起炎症 纸巾。

Project Summary/Abstract: Brucella infection causes a myriad of symptoms due to the ability of Brucella to infect almost any organ or organ system. Innate lymphoid cells are abundant in mucosal tissues which serve as a portal of entry for Brucella infection, and we have found that innate lymphoid cells regulate both inflammation and control of Brucella infection. In this proposal, we will investigate interactions between innate lymphoid cells and inflammasomes to determine how innate lymphoid cells from different tissues regulate Brucella-induced inflammation. We will also determine the relative contribution of different innate lymphoid cell subsets to controlling inflammation and Brucella infection. Collectively the results of our study will enhance our understanding of how Brucella is able to utilize mucosal sites as a portal of infection and cause inflammation within different host tissues.