New Approaches for Gene Mapping in Osteoporosis

骨质疏松症是世界上最常见的代谢性骨骼疾病，造成澳大利亚国内生产总值的1%。这是一种遗传性很强的疾病。我们最近在2000年完成了一项全基因组关联研究，研究对象是骨密度非常高或非常低的绝经后妇女，并确定了许多与骨密度有关的基因。目前的研究旨在使用下一代测序技术对这些女性进行更深入的基因研究，旨在更清楚地确定骨量的确切遗传决定因素。

Osteoporosis is the commonest metabolic bone disease worldwide, and costs Australia >1% of GDP. It is a strongly inherited disease. We recently completed a genome-wide association study in 2000 postmenopausal women with either very high or very low bone density, and identified many genes contributing to BMD. The current study aims to use next-generation sequencing to study these women in greater genetic depth, aiming to identify more clearly the exact genetic determinants of bone mass.