Pathology and Biorepository Core (Core B)

总结：病理学和生物储存库核心（核心B） MD安德森癌症中心转化研究的一个基本组成部分 SPORE是涉及人体组织和血液标本的重点转化研究， 研究靶组织和正常组织的生物学，并评估对靶组织和正常组织的治疗效果。 正常组织和特定的相关生物标志物的调节。病理学和生物储存核心 收集、处理和保存患者的人体组织标本，并将这些组织分散， 组织来源的原代胶质瘤干细胞（GSC）。它是一种有效的资源， 现有的SPORE项目严重依赖于组织，并将继续在 提出了未来的SPORE项目。 病理学和生物储存核心的具体目标是： 目标1：组织库。维持和加强现有的神经胶质瘤组织库，神经胶质瘤干细胞（GSC） 细胞系和患者匹配的血液标本，来源于MDACC患者。 目标2：资源分配。向SPORE研究者提供胶质瘤组织、GSC和匹配血液， 促进基础、转化和临床前研究。 目标3：病理学专业知识和基本服务。为组织病理学提供全面支持， 免疫组织化学和人类组织标本以及产生的样品的分子表征 从动物模型到孢子研究的过程。 目标4：综合数据库。支持一个全面、集成的数据库， 病理学和放射学数据，以及生物库中患者来源的组织资源。 目标5：孢子间合作。通过共享组织资源促进SPORE间的合作。

SUMMARY: PATHOLOGY AND BIOREPOSITORY CORE (CORE B) A fundamental component of the translational research of the MD Anderson Cancer Center Brain Cancer SPORE is conduct of focused translational research involving human tissue and blood specimens, allowing investigation of the biology of target and normal tissues, and evaluation of treatment effects on both target and normal tissue and on modulation of specific, relevant biomarkers. The Pathology and Biorepository Core collects, processes and maintains human tissue specimens from patients and will disperse these tissues and tissue-derived primary glioma stem cell (GSC) to SPORE investigators. It has been an effective resource for the existing SPORE projects, which are heavily tissue-dependent and will continue to serve this function in the proposed SPORE Projects going forward. The specific aims of the Pathology and Biorepository Core are these: Aim 1: Tissue banking. Maintain and enhance the existing repository of glioma tissue, glioma stem cell (GSC) lines, and patient-matched blood specimens, derived from MDACC patients. Aim 2: Resource distribution. Provide glioma tissue, GSCs, and matched blood to SPORE investigators to facilitate basic, translational, and preclinical investigations. Aim 3: Pathology expertise and essential services. Provide comprehensive support for the histopathological, immunohistochemical, and molecular characterization of human tissue specimens as well as samples generated from animal models through the course of SPORE investigations. Aim 4: Integrated data basing. Support a comprehensive, integrated database linking detailed clinical, pathological, and radiographic data with patient-derived tissue resources in the biorepository. Aim 5: Inter-SPORE collaboration. Facilitate inter-SPORE collaborations through sharing of tissue resources.