Biostats Core (TBD)

项目摘要--生物统计和生物信息学核心3 P01申请《肿瘤的分子靶向放射性治疗》的总体目标 “免疫调节和增强免疫治疗反应”是建立一个广泛的机制的理解 分子靶向核素治疗的免疫调节能力是下一代 提高免疫“热”和“冷”肿瘤治疗水平的免疫疗法。这个 生物统计学和生物信息学核心(BBC)的首要目标是促进临床前研究的卓越 在这份P01申请中提出的翻译研究，通过提供专门和杰出的咨询和 为P01提供生物统计、生物信息学和研究数据管理方面的协作支持和专业知识 项目1-4、行政核心、核心1(放射性核素生产和放射化学核心)和核心2 (高级成像和剂量学核心)，并根据需要。 生物统计部分将为所有四个项目和两个核心提供支助。生物统计队抽签 它的实力来自于与P01研究人员多年合作的生物统计学教师。生物统计学 对项目1和核心2(高级成像和剂量测定核心)的支持将是描述性和探索性的 在剂量学研究中涉及统计建模和估算。对项目2--生物统计的支持 4将涉及统计建模和推论，具有可比性。 生物信息学部分提议为项目2-4提供支助。生物信息学团队将其 来自与P01调查人员积极合作的生物信息学教员的力量。更确切地说， 它将提供生物信息学支持和分析专业知识，包括1)T细胞受体序列数据，2)RNAseq 与对照肿瘤相比，来自小鼠选择性肿瘤的数据显示肿瘤被根治 以及接受次优治疗导致免疫治疗失败的肿瘤，以及3)单细胞RNAseq 数据。 在支持行政核心和P01的总体上，BBC将使用 关系数据库管理系统，将作为所有项目和核心的记录数据库 本P01。BBC将使用该数据库在研究数据管理方面提供支持，该数据库将保存所有 从P01的项目和核心产生的数据，并作为中央数据中心，所有 将以生物统计学和生物信息学分析为基础。

PROJECT SUMMARY – BIOSTATISTICS AND BIOINFORMATICS CORE 3 The overarching goal of the P01 application “Molecular Targeted Radionuclide Therapy for Tumor Immunomodulation and Enhancing Immunotherapy Response” is to develop a broad mechanistic understanding of the immunomodulatory capacity of molecular targeted radionuclide therapy as part of the next generation of immunotherapy approaches to improve the treatment of immunologically “hot” and “cold” tumors. The overarching goal of the Biostatistics and Bioinformatics Core (BBC) is to promote excellence in pre-clinical translation research proposed in this P01 application by providing dedicated and outstanding consultation and collaborative support and expertise in biostatistics, bioinformatics and research data management for the P01 Projects 1-4, Administrative Core, Core 1 (Radionuclide Production and Radiochemistry Core), and Core 2 (Advanced Imaging and Dosimetry Core), and as needed. The biostatistics component will provide support for all four projects and two cores. The biostatistics team draws its strength from biostatistics faculty with many years of collaboration with the P01 investigators. Biostatistics support for Project 1 and Core 2 (Advanced Imaging and Dosimetry Core) will be descriptive and exploratory in nature and involve statistical modeling and estimation in dosimetry studies. Biostatistics support for Projects 2- 4 will involve statistical modeling and inference and will be comparative in nature. The bioinformatics component proposes to provide support for Projects 2-4. The bioinformatics team draws its strength from bioinformatics faculty who have active collaboration with the P01 investigators. More specifically, it will provide bioinformatics support and analysis expertise with 1) T cell receptor sequence data, 2) RNAseq data from selective tumors of mice that show curative eradication of tumors in comparison with control tumors and to tumors receiving sub-optimal therapy resulting in escape of immunotherapy, and 3) single cell RNAseq data. In supporting the Administrative Core and the P01 overall, the BBC will develop a P01-wide database using a relational database management system that will serve as the database of record for all projects and cores for this P01. The BBC will provide support in research data management using this database, which will hold all data generated from the Projects and Cores of the P01 and serve as the central data hub upon which all biostatistics and bioinformatics analyses will be based.