Optimization of a Combined Drug and Delivery Device for Treatment of Cyanide Poisoning

首席研究员/项目主任（最后，第一，中间）：帕特森，史蒂芬E。 项目总结/摘要 在恐怖袭击中使用氰化物造成大规模伤亡的风险是真实的，氰化物包括在 化学威胁风险评估（CTRA）作为回应，NIH CounterACT负责开发 有效的医疗对策，该项目的重点是开发有效的药物/器械 联合使用，为接触氰化物的受害者提供我们的速效解毒剂，磺胺。我们有 先前证明了磺胺原，一种在我们实验室中发现的新型氰化物拮抗剂，（Patterson， 在小鼠、猪和兔模型中， 氰化物暴露我们对磺胺的疗效的证明包括剂量优化，药代动力学， 物种论证、配方优化和安全性评估。为了进一步发展我们的 为了采取对策，Windgap Medical的自动注射器设计将进行定制，以适应磺胺剂的使用。 给药特性Windgap Medican-Minnesota财团的最终目标是：1）获得 IND/IDE从FDA，2）进行临床试验和3）FDA批准的动物规则。的重点 因此建议开发一种优化的组合自动注射器/磺胺原电极导线， 根据PAR-16-331，在非GLP研究中证明该电极导线的有效性和安全性，以及 为巴尔达下的下一轮资助奠定基础，这将使IND能够进行研究。

Principal Investigator/Program Director (Last, First, Middle): Patterson, Steven E. Project Summary/Abstract The risk of cyanide use in a terrorist attack resulting in a mass casualties is genuine and cyanide is included on the Chemical Threat Risk Assessment (CTRA) list. In response the NIH CounterACT charge to develop effective medical countermeasures, this project is focused on development of an effective drug/device combination to deliver our rapidly acting antidote, sulfanegen, to victims of cyanide exposure. We have previously demonstrated that sulfanegen, a novel cyanide antagonist discovered in our labs, (Patterson, Center for Drug Design) is effective in reversing lethal cyanide toxicity in murine, swine and rabbit models of cyanide exposure. Our demonstration of sulfanegen’s efficacy includes dose optimization, pharmacokinetics, species justification, formulation optimization, and safety assessment. In order to furthere develop our countermeasure, Windgap Medical’s autoinjector design will be customized to accommodate sulfanegen’s dosing characteristics. The Windgap Medican-Minnesota consortium’s ultimate goals are to 1) obtain an IND/IDE from the FDA, 2) conduct clinical trials and 3) FDA approval under the animal rule. The focus of this proposal is therefore on development of an optimized combined autoinjector/sulfanegen lead, demonstration of this lead’s efficacy and safety in non-GLP studies according to PAR-16-331, and establish the basis for a later round of funding under BARDA that will allow IND enabling studies.