Resource-based Center for the study of the joint microenvironment in rheumatology (Overall Application)

总体摘要 我们将在加州大学圣地亚哥分校建立风湿病研究资源中心 (加州大学洛杉矶分校)。我们在关节炎资源机读目录(MARC)中的微环境的主题是促进翻译 研究集中在关节炎的关节微环境上。对原位关节生物学和 风湿病的致病机制阻碍了新生物标记物和治疗方法的发展 以关节结构内的细胞相互作用为目标。MARC将通过刺激以下方面的兴趣来解决这一差距 一个由来自多个国家的资金雄厚的科学家组成的大型跨学科小组的联合微环境 圣地亚哥的机构。MARC的目标是为圣地亚哥科学界提供一个 全面的地方框架，以规划、执行和分析各种联合微环境研究 使用侵入性和非侵入性技术，培养新颖、协作和跨学科的关节炎- 相关研究。该中心的头两个目标是促进对组织微环境的研究 提供(AIM 1)尖端联合成像技术和方法，以分离单个细胞和 来自关节的组织和(目标2)专注于整合不同的多个 维度数据集。目标3是降低新调查人员进入该领域的门槛，并促进 圣地亚哥各地专注于风湿病的科学家之间的合作。这将通过以下方式实现 丰富计划，其中包括核心服务的凭证、试点和可行性赠款资金，以及 创建新的关节炎研讨会系列和以关节炎为重点的地区性研讨会，以促进合作。 圣地亚哥科学界根深蒂固地结合了创造力、活力、协作性 对翻译的态度和专注。因此，我们的中心将处于独特的地位，以促进新颖的科学 这将对风湿病的诊断和治疗产生革命性的影响。

OVERALL ABSTRACT We will establish a Rheumatic Diseases Research Resource Center at the University of California, San Diego (UCSD). The theme of our Microenvironment in Arthritis Resource MARC (MARC) is to facilitate translational research focused on the joint microenvironment in arthritis. Limited knowledge of in situ joint biology and pathogenic mechanisms in rheumatic diseases has prevented development of novel biomarkers and therapies that target cellular interactions within joint structures. The MARC will address this gap by stimulating interest in the joint microenvironment among a large interdisciplinary group of well-funded scientists from multiple institutions in San Diego. The goal of the MARC is to provide the San Diego scientific community with a comprehensive local framework to plan, perform and analyze a large variety of joint microenvironment studies using invasive and non-invasive technology and foster novel, collaborative, and interdisciplinary arthritis- relevant research. The first two Aims of the Center are to facilitate studies on tissue microenvironment by providing access to (Aim 1) cutting-edge joint imaging technology and approaches to isolate single cells and tissue from joints and to (Aim 2) a dedicated computational service focusing on integration of diverse multi- dimensional datasets. Aim 3 is to lower the barrier for new investigators to enter the field and to foster collaboration between rheumatic disease-focused scientists across San Diego. This will be accomplished via an Enrichment Program, which includes vouchers for core services, pilot and feasibility grant funding, and creation of a new arthritis seminar series and a regional arthritis-focused symposium to stimulate collaboration. The San Diego science community has a deeply rooted combination of creativity, dynamism, collaborative attitude and focus on translation. Thus, our Center will be uniquely positioned to facilitate the novel science that will be transformative for the diagnosis and treatment of rheumatic diseases.