Career Enhancement Program

由于进入该领域的新研究人员很少，前列腺癌的研究受到了极大的阻碍。在……里面 认识到有必要帮助建立转译前列腺癌领域的独立资助的研究人员 在癌症研究方面，密歇根前列腺孢子每年资助两到三名初级教员。的关注点 职业提升计划(CEP)是为调查人员提供产生初步数据的资源 用于后续的NIH R01拨款申请或未来的孢子项目。密歇根前列腺癌的孢子 每位调查员每年6万美元。职业提升奖获得者的资助期限最长为两年， 须接受年度审查。获奖者的部门每年还提供10,000美元的等额资金。 调查人员中的许多人都不在前列腺癌领域，他们每季度与联席董事会面一次。 Diane Robins博士(U-M)，Goutham Narla，M.D.，Ph.D.(U-M)和Jennifer Beebe-Dimmer，M.P.H. (KCI卡马诺斯癌症研究所)。罗宾斯博士是人类遗传学教授，在 新的癌症生物学计划，并曾担任该系研究生学习主任 遗传学。罗宾斯博士是CEP的基础科学导师。基因医学部主任纳拉博士， 是一名医学遗传学家，负责密歇根医学的癌症遗传学服务。他也是一名律师 密歇根大学MSTP项目主任。他将担任CEP的临床研究导师。毕比-迪默博士 是韦恩州立大学肿瘤学副教授，人口研究和 他是KCI的差异研究计划和流行病学研究中心主任。她将担任一名 人口科学和多样性研究导师。职业提升调查员的进展是 每年通过向运营委员会提交报告进行监督，如果调查人员 没有履行他们对转译前列腺癌研究的承诺。自1995年以来，我们的CEP一直在投资 在该项目中投资350万美元，并支持26名调查人员。作为回报，CEP调查人员产生了一个 在随后的赠款中获得了令人印象深刻的4780万美元，并在此期间制作了124份手稿。这个 这一计划的有效性体现在以下事实上：十名职业发展调查员(摩根博士， Tomlins、Salami、Pitchiaya、Spratt、Cooney、Chinnaiyan、魏、洛伯格和冯)已成为项目联合- 密歇根前列腺癌孢子项目的领导者。在这项提案中，CEP将由密歇根大学和墨尔本大学联合支持 KCI。密歇根大学将捐赠7万美元以上的资金，用于支付密歇根大学联席董事的工作费用。的KCI组件 密歇根州前列腺癌孢子将以每年60,000美元的价格资助每年1个CEP，或以每年50,000美元的价格资助1个DRP 年。以及资助KCI联席董事的资金。我们要求NCI提供剩余的50,000美元。

Prostate cancer research has been greatly hindered by the paucity of new investigators entering the field. In recognition of the need to help establish independently funded investigators in the field of translational prostate cancer research, the Michigan Prostate SPORE has supported two to three junior faculty per year. The focus of the Career Enhancement Program (CEP) is to provide investigators the resources to generate preliminary data for subsequent NIH R01 grant applications or future SPORE projects. The Michigan Prostate SPORE commits $60,000 annually per investigator. Career Enhancement awardees are funded for a maximum of two years, subject to annual review. The awardees’ departments supply another $10,000 per year in matching funds. Investigators, many of whom are outside the field of prostate cancer, meet quarterly with the Co-Directors, Drs. Diane Robins, Ph.D. (U-M), Goutham Narla, M.D., Ph.D. (U-M) and Jennifer Beebe-Dimmer, M.P.H., Ph.D. (Karmanos Cancer Institute, KCI). Dr. Robins is a Professor of Human Genetics and has a leadership role in the new Cancer Biology Program and has served previously as Director of graduate studies in the Department of Genetics. Dr. Robins is the basic science mentor for the CEP. Dr. Narla, chief of the Division of Genetic Medicine, is a medical geneticist who directs cancer genetics services at Michigan Medicine. He is also an associate director of the MSTP program at U-M. He will serve as the clinical research mentor for CEP. Dr. Beebe-Dimmer is an Associate Professor of Oncology, at Wayne State University and the Leader of the Population Studies and Disparities Research Program and Director of the Epidemiology Research Core at the KCI. She will serve as a population sciences and diversity research mentor. The progress of the Career Enhancement investigators is monitored yearly by presentation to the Operating Committee and funding can be terminated if the investigators are not fulfilling their commitment to translational prostate cancer research. Since 1995, our CEP has invested $3.5 million in the program and supported 26 investigators. In return, the CEP investigators have generated an impressive $47.8 million in subsequent grants and produced 124 manuscripts during that time period. The effectiveness of this program is reflected by the fact that ten career development investigators (Drs. Morgan, Tomlins, Salami, Pitchiaya, Spratt, Cooney, Chinnaiyan, Wei, Loberg and Feng) have become project Co- Leaders in the Michigan Prostate SPORE program. In this proposal, CEP will be jointly supported by U-M and KCI. U-M will contribute $70,000 plus funds to cover effort for the U-M Co-Directors. The KCI component of the Michigan Prostate SPORE will fund either 1 CEP per year at $60,000 per year or 1 DRP per year at $50,000 per year. as well as funds to cover the KCI Co-Director. We are requesting the remaining $50,000 from NCI.