Project 2

考虑到抗药性挑战的艰巨范围，需要一种强有力的团队科学方法。 运用一整套翻译研究方法，以提供变革性的 将影响患者护理的突破。除了管理财政和预算监督外，我们还将 协调定期的协作会议过程，由绩效指标和项目经理协调，以 确保数据解释和实验设计的实时协作数据共享和集体输入。 我们将建立共享资源“核心”，为研究人员提供此DrSc中的几个密钥 对于我们的研究项目组合的成功至关重要的能力。这些共享资源将 包括(1)患者衍生器官生成，(2)液体活检，(3)基因组学和(4)组织采集， 资源的分配将由私人投资促进机构和项目经理监督。 行政核心还将与联合国开发计划署协作领导结构的主要组成部分对接 DRSC包括： 1)项目联合负责人--Dr。贝内斯(项目1)、海斯特博士(项目2)、哈科恩博士(项目3) 2.)疾病中心领导-Shaw博士(肺部)、Flaherty博士(黑色素瘤)、Corcoran博士(GI) 3.)共享资源核心领导力-Benes/Yilmaz博士(患者衍生模型)、Haco hen博士/Getz (基因组学)，Juric博士(组织获取)，液体活检(Adalsteinsson，Corcoran博士) 4.)博士咨询委员会-哈伯博士、查布纳博士、瑞安博士、哈恩博士、戈卢布博士 行政核心的一个主要目标将是促进项目团队内部、项目之间的合作 团队，以及其他DrSc站点和NCI。

Given the daunting scope of the challenge of drug resistance, a strong team science approach will be needed to bring a full array of translational research approaches to bear in order to deliver transformative breakthroughs that will impact patient care. In addition to managing fiscal and budgetary oversight, we will coordinate a regular process of collaborative meetings, to be coordinated by the PIs and Project Manager to ensure real-time collaborative data sharing and collective input on data interpretation and experimental design. We will establish shared resource “cores” to provide investigators in this DRSC ready access to several key capabilities that will be crucial for the success of our research project portfolio. These shared resources will include (1) Patient-derived Organoid Generation, (2) Liquid Biopsy, (3) Genomics and (4) tissue acquisition, and allocation of resources will be overseen by the PIs and the Project Manager. The Administrative Core will also interface with key components of the collaborative leadership structure of the DRSCincluding: 1.) Project co-Leaders--Dr. Benes (Project 1), Dr. Heist (Project 2), Dr. Hacohen (Project 3) 2.) Disease Center Leadership—Dr. Shaw (lung), Dr. Flaherty (melanoma), Dr. Corcoran (GI) 3.) Shared Resource Core Leadership—Drs. Benes/Yilmaz (Patient-derived models), Drs. Hacohen/Getz (Genomics), Dr. Juric (Tissue acquisition), Liquid Biopsy (Drs. Adalsteinsson, Corcoran) 4.) DRSC Advisory Board—Drs. Haber, Chabner, Ryan, Hahn, Golub A major goal of the Administrative Core will be to foster collaboration within project teams, between project teams, and with other DRSC sites and the NCI.