Core 2: Biostatistics and Bioinformatics

摘要-生物统计学和生物信息学核心（核心2） 生物统计学和生物信息学核心的使命是提供生物统计学和生物信息学专业知识 支持杜克癌症健康差异（DCHD）P20 SPORE中的癌症健康差异研究 程序.核心将作为应用和理论癌症生物统计学专业知识的集中资源 以及生物信息学、数据科学、机器学习和科学计算。核心将由特里共同领导 Hyslop博士和Kouros Owzar博士，他们拥有35年的癌症生物统计学和生物信息学经验 技术专长和领导能力，沿着他们在发展统计 混合人口的分析方法。核心使命将在框架内完成 良好的数据来源和统计原则，识字编程和可重复的分析。代码 将使用源代码管理软件跟踪分析结果，并公开分发。任何 本核心为支持拟议研究而重新扩展或开发的软件将被分发 提供给癌症研究界，并提供足够的文件和免费的公共许可证。核心2将 提供基础、临床和转化癌症生物统计学和生物信息学支持（目标1）; 统计和计算方法和工具（目标2）;并提供咨询和教育以支持当前 和未来的DCHD P20项目（目标3）。核心将提供癌症生物统计学和生物信息学专业知识 支持项目1和项目2提出的研究。这将确保这些项目清楚地 明确的量化目标，全面的数据质量控制计划，以及明确定义的中期和最终 分析计划使用适当的统计和计算方法，以及计算基础设施。核心 工作人员将编写中期和最终报告，进行项目数据检查和验证，并为以下工作做出贡献： 摘要、海报和手稿准备。对于项目1，核心将提供RNA测序分析 支持从原始读数和预处理的初始质量控制评估到下游统计 分析和注释。核心人员将积极配合拟定的生物标本/病理学 在测序设计的核心。对于项目2，核心小组提供了统计设计和分析计划， 拟议的研究，并将提供统计和数据管理支持，从招聘到最后 分析阶段。核心领导人将积极咨询和教育项目调查人员，以及 发展研究计划（DRP）和预职业发展计划（CEP）获奖者。这 将帮助研究人员更深入地了解他们的项目的定量结果，包括限制 从特定的实验设计中做出推论，以及正确解释他们的发现。 生物统计学和生物信息学核心服务于所有项目，咨询并与DRP和pre-CEP获奖者合作， 在执行委员会中有代表，并与生物标本/病理学核心和 行政核心。我们的服务对于实现DCHD P20 SPORE的共同目标至关重要。

ABSTRACT – Biostatistics and Bioinformatics Core (Core 2) The mission of the Biostatistics and Bioinformatics Core is to provide biostatistics and bioinformatics expertise in support of cancer health disparities research in the Duke Cancer Health Disparities (DCHD) P20 SPORE program. The Core will serve as a centralized resource for expertise in applied and theoretical cancer biostatistics and bioinformatics, data science, machine learning, and scientific computing. The Core will be co-led by Terry Hyslop, PhD, and Kouros Owzar, PhD, who have a combined 35 years of cancer biostatistics and bioinformatics technical expertise and leadership, along with their joint research expertise in development of statistical methodologies for analysis of admixed populations. The Core mission will be accomplished within the framework of sound data provenance and statistical principles, literate programming, and reproducible analysis. The code to reproduce analyses will be tracked using source code management software and disseminated publicly. Any software extended or developed de novo by this Core in support of the proposed research will be disseminated to the cancer research community with adequate documentation and under a free public license. Core 2 will provide basic, clinical, and translational cancer biostatistics and bioinformatics support (Aim 1); evaluate statistical and computational methods and tools (Aim 2); and provide consulting and education to support current and future DCHD P20 projects (Aim 3). The Core will provide cancer biostatistics and bioinformatics expertise in support of the research proposed by Project 1 and Project 2. This will ensure that the projects have clearly stated quantitative objectives, comprehensive data quality control plans, and clearly defined interim and final analysis plans using appropriate statistical and computational methodology, and computing infrastructure. Core personnel will produce interim and final reports, programmatic data checks and validation, and contribute to abstract, poster, and manuscript preparation. For Project 1, the Core will provide RNA sequencing analysis support from initial quality control assessment of raw reads and pre-processing, to downstream statistical analysis and annotation. Core personnel will actively collaborate with the proposed Biospecimen/Pathology Core in the sequencing design. For Project 2, the Core has provided the statistical design and analysis plan for the proposed studies and will provide statistical and data management support from the recruitment to the final analysis stage. Core leaders will actively consult with and educate program investigators, as well as Developmental Research Program (DRP) and pre Career Enhancement Program (pre-CEP) awardees. This will help investigators to more deeply understand their projects’ quantitative results, including both the limitations in making inferences from a particular experimental design, and also in proper interpretation of their findings. The Biostatistics and Bioinformatics Core serves all Projects, consults and works with DRP & pre-CEP awardees, is represented on the Executive Committee, and works closely with the Biospecimen/Pathology Core and the Administrative Core. Our services are crucial to achieving the shared goals of the DCHD P20 SPORE.