Do E-cigarette Design Features Impact Cigarette Initiation, Cessation & Relapse?

项目总结/摘要 电子尼古丁输送系统（“电子烟”）对人口水平的影响将在很大程度上取决于 它们对吸烟的影响。因此，当使用人口标准来确定 烟草监管决定，电子烟对吸烟开始，停止和复吸的影响 都必须考虑。美国国家科学、工程和医学院（NASEM）得出结论， 关于电子烟特性是否/如何影响向 和吸烟。拟议的项目将通过评估独立的 四种电子烟设计特征的影响，可以通过FDA的行动-口味，设备类型 特征、尼古丁含量和尼古丁配方-对以后吸烟开始、停止和 在美国的年轻人和成年人中复发。我们将分析2010年纵向人口评估的数据， 烟草与健康（PATH）研究，纵向国际烟草控制（ITC）青年 烟草和电子烟调查，以及ITC四国吸烟和电子烟调查的美国分支。我们 将使用广义估计方程回归分析以及倾向评分匹配技术 以增加统计功效并在统计上减少其他因素对关联的潜在混淆。 ·目标1将研究非吸烟青年和年轻人的电子烟使用和吸烟开始。 我们将研究电子烟的设计特征是否以及如何预测未来的吸烟行为， 包括发展为经常吸烟。 ·目标2将检查青少年和成年吸烟者的电子烟使用和戒烟情况。 我们将研究电子烟的设计特征是否以及如何影响后来的戒烟， 同时考虑设计功能的潜在范围和有效性。 ·目标3将检查成年前吸烟者的电子烟使用和香烟复发。我们将 研究电子烟的设计特征是否以及如何影响后来的吸烟复发。 共同实现这些目标将为电子烟设计的影响提供平衡的科学证据 在美国转向和远离吸烟的过渡特征-结果， 电子烟的净危害/益处潜力最终将取决于。这些发现可以直接告知FDA 关于电子烟口味、设备类型特征、尼古丁的产品标准的监管行动 含量和尼古丁制剂。

PROJECT SUMMARY/ABSTRACT The population-level impact of electronic nicotine delivery systems (“e-cigarettes”) will depend in large part on their effects on combustible tobacco cigarette smoking. Therefore, when using a population standard to make tobacco regulatory decisions, the impacts of e-cigarettes on cigarette smoking initiation, cessation, and relapse must all be considered. The National Academies of Sciences, Engineering, and Medicine (NASEM) concluded that there are key gaps in the literature regarding whether/how e-cigarette characteristics impact transitions to and from cigarette smoking. The proposed project will address these gaps by evaluating the independent effects of four e-cigarette design features that can be regulated by FDA action – flavors, device type characteristics, nicotine content, and nicotine formulation – on later cigarette smoking initiation, cessation, and relapse among youth and adult in the US. We will analyze data from the longitudinal Population Assessment of Tobacco and Health (PATH) Study, the US arm of the longitudinal International Tobacco Control (ITC) Youth Tobacco and E-cigarette Survey, and the US arm of the ITC Four Country Smoking and Vaping Survey. We will use generalized estimating equation regression analyses as well as propensity score matching techniques to increase statistical power and to statistically reduce potential confounding of associations by other factors. • Aim 1 will examine e-cigarette use and cigarette initiation among nonsmoking youth and young adults. We will examine whether and how e-cigarette design features predict future cigarette smoking initiation, including progression to regular cigarette smoking. • Aim 2 will examine e-cigarette use and cigarette cessation among youth and adult cigarette smokers. We will examine whether and how e-cigarette design features impact later cigarette smoking cessation, considering both the potential reach and effectiveness of design features. • Aim 3 will examine e-cigarette use and cigarette relapse among adult former cigarette smokers. We will examine whether and how e-cigarette design features impact later cigarette smoking relapse. Addressing these aims together will provide balanced scientific evidence of the impact of e-cigarette design features on transitions both toward and away from cigarette smoking in the US – the outcome upon which the net harm/benefit potential of e-cigarettes will ultimately hinge. These findings can directly inform FDA regulatory actions regarding product standards for e-cigarette flavors, device type characteristics, nicotine content, and nicotine formulation.